|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A;D |
|
Relevant Drug
|
tenofovir (TDF) |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
32663786
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2020 |
|
Journal
|
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
|
Title
|
Evidence of tenofovir resistance in chronic hepatitis B virus (HBV) infection: An observational case series of South African adults. |
|
Author
|
Mokaya J,Maponga TG,McNaughton AL,Van Schalkwyk M,Hugo S,Singer JB,Sreenu VB,Bonsall D,de Cesare M,Andersson M,Gabriel S,Taljaard J,Barnes E,Preiser W,Van Rensburg C,Matthews PC |
|
Evidence
|
M204I/V and L180M are best recognised in association with 3TC resistance, but they may also be part of a combination of polymorphisms that underpins TDF resistance as there was no sustained viral suppression.
|
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HBV Mutation Detail Information