HBV Mutation Detail Information

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Mutation Information

Mutation Site	L173V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204V+rt.L180M+rt.L173V

Literature Information

PubMed PMID	30202825
Disease	HBV infection
Published Year	2018
Journal	Hepatology communications
Title	Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis.
Author	Rose RE,Hernandez D,Falk PJ,Ericson K,Zhou N,Thiry A,McPhee F
Evidence	To investigate the role of the HBV rtA181C substitution in reduced ETV susceptibility, this substitution was introduced into a WT laboratory clone, an LVDr laboratory clone harboring LVDr substitutions rtL173V+rtL180M+rtM204V, and a recombinant clone from a patient (Pt19 harboring LVDr substitutions rtL173V+rtL180M+rtM204V.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation