|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
16197491
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2005 |
|
Journal
|
Alimentary pharmacology & therapeutics |
|
Title
|
Clinical reactivation during lamivudine treatment correlates with mutations in the precore/core promoter and polymerase regions of hepatitis B virus in patients with anti-hepatitis B e-positive chronic hepatitis. |
|
Author
|
Marrone A,Zampino R,Karayannis P,Cirillo G,Cesaro G,Guerrera B,Ricciotti R,del Giudice EM,Utili R,Adinolfi LE,Ruggiero G |
|
Evidence
|
The L180M substitution was detected in four of eight (50%) of group A and in none of groups B1 and B2.
|
|
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HBV Mutation Detail Information