HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	A
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	19263474
Published Year	2009
Journal	Hepatology (Baltimore, Md.)
Title	The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains.
Author	Amini-Bavil-Olyaee S,Herbers U,Sheldon J,Luedde T,Trautwein C,Tacke F
Evidence	We generated replication-competent HBV constructs harboring rtA194T alone or in addition to lamivudine (LAM) resistance (rt180M + rtM204V), PC mutations, and BCP mutations and assessed their replicative capacity after transient transfection inHuman hepatoma cells.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation