HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204V+rt.L180M+rt.A194T
Relevant Drug	tenofovir (TDF)

Literature Information

PubMed PMID	16218172
Disease	HBV-HIV coinfection
Published Year	2005
Journal	Antiviral therapy
Title	Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir.
Author	Sheldon J,Camino N,Rodés B,Bartholomeusz A,Kuiper M,Tacke F,Núñez M,Mauss S,Lutz T,Klausen G,Locarnini S,Soriano V
Evidence	Phenotypic analyses revealed that constructs harbouring rtA194T combined with rtL180M and rtM204V displayed an over 10-fold increase in the IC50 for TDF compared with the wild type.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation