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Mutation Information
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Mutation Site
|
A181V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.N236T+rt.A181V;rt.A181V;rt.M204I+rt.M204V+rt.N236T+rt.A181V;rt.A181V+rt.M204I+rt.M204V;rt.M250L+rt.M250I+rt.M250V+rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V+rt.N236T+rt.A181V;rt.M204I+rt.A181V;rt.M204V+rt.A181V+rt.L180M;rt.M204I+rt.A181V+rt.L80I;rt.N236T+rt.M204V+rt.A181V+rt.L180M+rt.L80I |
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Genotype/Subtype
|
B;C |
|
Relevant Drug
|
Adefovir(ADV) |
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Country
|
China |
Literature Information
|
PubMed PMID
|
27792585
|
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Disease
|
HBV infection
|
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Published Year
|
2017 |
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Journal
|
Microbial drug resistance (Larchmont, N.Y.) |
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Title
|
Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China. |
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Author
|
Li X,Liu Y,Xin S,Ji D,You S,Hu J,Zhao J,Wu J,Liao H,Zhang XX,Xu D |
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Evidence
|
For adefovir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtA181 V (HBV/C 5.29% vs. HBV/B 1.36%, p < 0.01) and a lower detection rate of rtN236T (2.70% vs. 6.54%, p < 0.01).
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HBV Mutation Detail Information