|
Mutation Information
|
Mutation Site
|
M552I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
p.L528M+rt.M552I |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10762559
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2000 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B. |
|
Author
|
Seignères B,Pichoud C,Ahmed SS,Hantz O,Trépo C,Zoulim F |
|
Evidence
|
Sequence analysis of the RT domain of resistant strains, at the time of breakthrough of virus, revealed the occurrence of mutations located in the YMDD motif within the C domain of the viral enzyme, with a methionine→valine (M552V) or methionine→isoleucine (M552I) change, as also described in human immunodeficiency virus strains resistant to lamivudine
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|
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HBV Mutation Detail Information