HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	lamivudine (LAM);telbivudine (LDT)
Country	Vietnam

Literature Information

PubMed PMID	22720022
Disease	HBV-HCV-HIV coinfection
Published Year	2012
Journal	PloS one
Title	A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Author	Dunford L,Carr MJ,Dean J,Nguyen LT,Ta Thi TH,Nguyen BT,Connell J,Coughlan S,Nguyen HT,Hall WW,Thi LA
Evidence	All were coinfected with HIV and were receiving lamivudine as a component of HAART. 78.9% (n = 15/19) of these individuals had undetectable HBV viral loads and, of the 4 patients on HAART with a detectable HBV viral load, one - a HIV/HBV/HCV coinfected IDU - had drug resistance associated mutations, L180M and M204V in the pol gene conferring resistance to lamivudine and possible resistance to telbivudine.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation