HBV Mutation Detail Information

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Mutation Information

Mutation Site	A181T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	s.W172L+rt.A181T
Amino acid_Mutation	A527T
Genotype/Subtype	C
Relevant Drug	lamivudine (LAM)
Country	Japan

Literature Information

PubMed PMID	16982790
Disease	Chronic hepatitis B
Published Year	2006
Journal	Antimicrobial agents and chemotherapy
Title	Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.
Author	Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K
Evidence	The detected nucleotide substitution was accompanied by the emergence of an additional nucleotide substitution that induced amino acid change (S331C) in the spacer domain. The rtA181T mutant strain displayed a threefold decrease in susceptibility to lamivudine in in vitro experiments in comparison with the wild type.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation