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Mutation Information
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Mutation Site
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F122Y |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
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A;D |
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Relevant Drug
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tenofovir (TDF) |
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Country
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South Africa |
Literature Information
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PubMed PMID
|
32663786
|
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Disease
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Chronic hepatitis B
|
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Published Year
|
2020 |
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Journal
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Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
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Title
|
Evidence of tenofovir resistance in chronic hepatitis B virus (HBV) infection: An observational case series of South African adults. |
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Author
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Mokaya J,Maponga TG,McNaughton AL,Van Schalkwyk M,Hugo S,Singer JB,Sreenu VB,Bonsall D,de Cesare M,Andersson M,Gabriel S,Taljaard J,Barnes E,Preiser W,Van Rensburg C,Matthews PC |
|
Evidence
|
At a deep sequence level, the RAMs we observed in all three patients were present in >95 % of HBV reads. Polymorphism in HBV RT Frequency in genotype A sequences Frequency in genotype D sequences Y9H 286/ 290 (98.6 %) 556/566 (98.2 %) L91I 290/290 (100 %) 41/566 (7.2 %) F122Y/L 8/290 (2.8 %) 82/566 (14.5 %) H/126Y 225/290 (77.6 %) 4/566 (0.7 %) R153W 228/290 (78.6 %) 22/566 (3.9 %) V173L 0/290 (0%) 4/566 (0.7 %) L180M 7/290 (2.4 %) 13/566 (2.3 %) M204I/V 7/290 (2.4 %) 25/566 (4.4 %) S223A 289/290 (99.7 %) 563/566 (99.5 %) C256S 279/290 (96.2 %) 65/566 (11.5 %) D263E 1/290 (0.3 %) 111/566 (19.6 %) V278I 16/290 (5.5 %) 55/566 (9.7 %) A317S 4/290 (1.4 %) 531/566 (93.8 %) Frequency of putative TDF RAMs in genotype A (n = 290) and D (n = 566) HBV sequences downloaded from Hepatitis B Virus Database (HBVdb), https://hbvdb.ibcp.fr/HBVdb/.
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HBV Mutation Detail Information