HBV Mutation Detail Information

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Mutation Information

Mutation Site	T268S
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Country	China

Literature Information

PubMed PMID	29287068
Disease	Hepatocellular carcinoma
Published Year	2017
Journal	PloS one
Title	Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.
Author	Yin F,Xie Y,Fan H,Zhang J,Guo Z
Evidence	Of these 86 sites, the following 19 were associated with postoperative survival at statistically significant levels (P<0.05) in HCC tissue based on the log-rank test with the Kaplan–Meier method (Table 3): nucleotides 2525 (Asp73Glu), 2733 (Lys143Gln), 2738, 2768, 2946 (Val210Ile), 3063, 3066 (Pro249Ser), 3109 (Thr268Ser), 31 (Ser314Pro), 529 (Asp480Asn), 735, 939, 1078 (Ser663Ala), 1137, 1383, 1461, 1485, 1544 (Val818Asp or Val818Ala); and 1613 (Arg841Lys).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation