|
Mutation Information
|
Mutation Site
|
N236T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A;D |
|
Relevant Drug
|
adefovir (ADV) |
|
Country
|
Germany |
Literature Information
|
PubMed PMID
|
22892524
|
|
Disease
|
HBV infection
|
|
Published Year
|
2012 |
|
Journal
|
Antiviral therapy |
|
Title
|
Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy. |
|
Author
|
van Bömmel F,Trojan J,Deterding K,Wedemeyer H,Wasmuth HE,Hüppe D,Möller B,Bock FJ,Feucht HH,Berg T |
|
Evidence
|
To assess the clinical relevance of this cross-resistance, we studied the evolution of HBV polymerase gene variants in patients with genotypic resistance against ADV (rtN236T and/or rtA181V/T) during TDF treatment.
|
|
|
HBV Mutation Detail Information