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Mutation Information
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Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V207I+rt.M204V+rt.S202G+rt.L180M |
|
Genotype/Subtype
|
A |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
22666402
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2012 |
|
Journal
|
PloS one |
|
Title
|
Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome. |
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Author
|
Rodriguez-Frías F,Tabernero D,Quer J,Esteban JI,Ortega I,Domingo E,Cubero M,Camós S,Ferrer-Costa C,Sánchez A,Jardí R,Schaper M,Homs M,Garcia-Cehic D,Guardia J,Esteban R,Buti M |
|
Evidence
|
On linkage analysis of the RT region studied, NA-resistant HBV variants (except for rtA181T) were present in combinations of amino acid substitutions that increased in complexity after viral breakthrough to entecavir, at which time the combined variant rtL180M-S202G-M204V-V207I predominated.
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HBV Mutation Detail Information