|
Mutation Information
|
Mutation Site
|
L199V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
24696492
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Journal of virology |
|
Title
|
The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene. |
|
Author
|
Ahn SH,Park YK,Park ES,Kim JH,Kim DH,Lim KH,Jang MS,Choe WH,Ko SY,Sung IK,Kwon SY,Kim KH |
|
Evidence
|
At viral breakthrough during LMV treatment, three conserved mutations (L80I, L199V, and M204I) were predominantly detected and colocalized on the same genome (the clone 22 series).
|
|
|
HBV Mutation Detail Information