HBV Mutation Detail Information

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Mutation Information

Mutation Site	H216H
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.H216H+s.I208T
Amino acid_Mutation	T777C
Genotype/Subtype	D
Relevant Drug	lamivudine (LAM)
Country	India

Literature Information

PubMed PMID	16428891
Disease	Chronic hepatitis B
Published Year	2006
Journal	Intervirology
Title	Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India.
Author	Kazim SN,Sarin SK,Sharma BC,Khan LA,Hasnain SE
Evidence	Following lamivudine therapy, 14 of 57 (24.5%) patients developed 16 types of S-gene mutations (sP120S, sA128V, sS143L, sW182St., sT189I, sV190A, sS193L, sI195M, sW196L, sW196St., sS207R, sI208T, sS210E, sF219S, sF220L and sC221G).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation