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Mutation Information
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Mutation Site
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D134E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.M204V+rt.L180M+rt.D134E+rt.H126Y+rt.S106C;rt.M204V+rt.L180M+rt.V173L+rt.D134E+rt.H126Y+rt.S106C;rt.M204I+rt.D134E+rt.H126Y+rt.S106C;rt.M204I+rt.L180M+rt.L80I+rt.D134E+rt.H126Y+rt.S106C;rt.M204V+rt.L180M+rt.V173L+rt.L269I+rt.D134E+rt.H126Y+rt.S106C;rt.M204I+rt.L180M+rt.L80I+rt.L269I+rt.D134E+rt.H126Y+rt.S106C;rt.L229M+rt.M204I+rt.L269I+rt.D134E+rt.H126Y+rt.S106C;rt.A181V+rt.L269I+rt.D134E+rt.H126Y+rt.S106C;rt.N236T+rt.L269I+rt.D134E+rt.H126Y+rt.S106C |
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Relevant Drug
|
lamivudine (LAM);adefovir dipivoxil (ADV);tenofovir (TFV) |
Literature Information
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PubMed PMID
|
32894807
|
|
Disease
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Chronic hepatitis B
|
|
Published Year
|
2021 |
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Journal
|
Journal of viral hepatitis |
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Title
|
Characterization of Hepatitis B virus polymerase mutations A194T and CYEI and tenofovir disoproxil fumarate or tenofovir alafenamide resistance. |
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Author
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Liu Y,Chang S,Martin R,Flaherty J,Mo H,Feierbach B |
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Evidence
|
Both the A194T and a quadruple mutation CYEI (S106C, H126Y, D134E and L269I) in hepatitis B virus (HBV) polymerase reverse transcriptase domain (pol/RT) are suggested to be associated with treatment failure with tenofovir disoproxil fumarate (TDF).
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HBV Mutation Detail Information