|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
12167344
|
|
Published Year
|
2002 |
|
Journal
|
Virology |
|
Title
|
Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene. |
|
Author
|
Torresi J,Earnest-Silveira L,Civitico G,Walters TE,Lewin SR,Fyfe J,Locarnini SA,Manns M,Trautwein C,Bock TC |
|
Evidence
|
The two most common LMV-resistant mutants produce changes in the viral polymerase protein (rt) of rtM204I and rtL180M/M204V (previously rtM550I and rtL526M/M550V).
|
|
|
HBV Mutation Detail Information