HBV Mutation Detail Information

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Mutation Information
Mutation Site M204V
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Viral Reference X75665.1
Relevant Drug lamivudine (LAM)
Country Japan;United States; Hong Kong
Literature Information
PubMed PMID 19933798
Disease Chronic hepatitis B
Published Year 2010
Journal Antimicrobial agents and chemotherapy
Title Mechanism of entecavir resistance of hepatitis B virus with viral breakthrough as determined by long-term clinical assessment and molecular docking simulation.
Author Mukaide M,Tanaka Y,Shin-I T,Yuen MF,Kurbanov F,Yokosuka O,Sata M,Karino Y,Yamada G,Sakaguchi K,Orito E,Inoue M,Baqai S,Lai CL,Mizokami M
Evidence Multivariate logistic regression analysis adjusted for age, gender, HBV DNA levels, and LVD resistance (LVDr) (L180M and M204V, but not M204I) indicated that T184 substitutions and S202G (not S202C) were a significant factor for BT (adjusted odds ratio [OR], 141.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation