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Mutation Information
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Mutation Site
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D263E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Genotype/Subtype
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A;D |
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Relevant Drug
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tenofovir (TDF) |
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Country
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South Africa |
Literature Information
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PubMed PMID
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32663786
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Disease
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Chronic hepatitis B
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Published Year
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2020 |
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Journal
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Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
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Title
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Evidence of tenofovir resistance in chronic hepatitis B virus (HBV) infection: An observational case series of South African adults. |
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Author
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Mokaya J,Maponga TG,McNaughton AL,Van Schalkwyk M,Hugo S,Singer JB,Sreenu VB,Bonsall D,de Cesare M,Andersson M,Gabriel S,Taljaard J,Barnes E,Preiser W,Van Rensburg C,Matthews PC |
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Evidence
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This individual also had concurrent large flares in liver enzymes (Figure 2 C Figure 2C). Genomic evidence of TDF resistance Patient ID 209 258 289 Treatment TDF + 3TC + FTC TDF + 3TC + FTC TDF Age range at recruitment 41-50 41-50 61-70 HIV status Positive Positive Negative Elastography score (kPa) 6.9 5.1 9.1 HBV DNA viral load, log10 IU/mL at time of sequencing 8.03 6.77 8.18 HIV RNA viral load, log10 copies/mL at time of sequencing 1.74 4.97 N/A Median coverage/site 4262 1601 14 HBV Genotype A D A Reverse transcriptase (RT) polymorphisms potentially associated with TDF resistance Y9H Y9H Y9H L91I F122L L91I H126Y S223A H126Y R153W* D263E S223A V173L*, V278I C256S L180M*, A317S M204V*, S223A C256S Summary of patient characteristics and HBV sequence data generated from three South African adults.
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HBV Mutation Detail Information