Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Mutation Detail Information

> M250I Search Result


Mutation Information
Mutation Site M250I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Viral Reference U95551
Literature Information
PubMed PMID 23261845
Published Year 2013
Journal Antiviral research
Title The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir.
Author Qin B,Budeus B,Cao L,Wu C,Wang Y,Zhang X,Rayner S,Hoffmann D,Lu M,Chen X
Evidence In contrast, pHBV-rtF249A and -rtM250I only produced RC DNA bands and their levels were 12.9% and 25.8% as compared to that of pHBV1.3, respectively (Fig. 1C, lower panel), which suggest that these two aa substitutions may impair the RT activity of HBV polymerase.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation