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Mutation Information
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Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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entecavir (ETV);lamivudine (LAM);adefovir (ADV) |
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Country
|
China |
Literature Information
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PubMed PMID
|
29630974
|
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Disease
|
HBV infection
|
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Published Year
|
2018 |
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Journal
|
Antiviral research |
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Title
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Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation. |
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Author
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Zhao L,Li X,Cheng Y,Chen R,Shao J,Zhou Y,Li Q,Liao H,Zhao Y,Liu L,Su H,Liu Y,Liu Y,Xu D |
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Evidence
|
44.33% (524/1182) rtA181T-positive samples were detected with signature drug-resistant mutations, including 325 with adefovir-resistant mutation rtA181V/N236T, 57 with lamivudine-resistant mutation rtM204V/I, 99 with entecavir-resistant mutation rtM204V/I plus rt184/202/250 substitution(s), and 43 with multidrug-resistant mutation rtA181V/N236T + rtM204V/I +- rt184/202/250 substitution(s).
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HBV Mutation Detail Information