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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
29039614
|
|
Published Year
|
2017 |
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Journal
|
Molecular medicine reports |
|
Title
|
Substitutions of rtL228 and/or L229 are involved in the regulation of replication and HBsAg secretion in hepatitis B virus, and do not affect susceptibility to nucleos(t)ide analogs. |
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Author
|
Qin B,Zhou Y,Zhou G,Xu X,Wang Y,Chen J |
|
Evidence
|
The mutation rtM204V/I was demonstrated to weaken HBV replication, while rtL180M was able to restore the impaired replication capacity, in accordance with a previous report
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HBV Mutation Detail Information