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Mutation Information
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Mutation Site
|
M552V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
10762559
|
|
Clinical information
|
Yes
|
|
Disease
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Chronic hepatitis B
|
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Published Year
|
2000 |
|
Journal
|
The Journal of infectious diseases |
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Title
|
Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B. |
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Author
|
Seignères B,Pichoud C,Ahmed SS,Hantz O,Trépo C,Zoulim F |
|
Evidence
|
Sequence analysis of the RT domain of resistant strains, at the time of breakthrough of virus, revealed the occurrence of mutations located in the YMDD motif within the C domain of the viral enzyme, with a methionine→valine (M552V) or methionine→isoleucine (M552I) change, as also described in human immunodeficiency virus strains resistant to lamivudine
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HBV Mutation Detail Information