Overview of HIV Mutation, Integration-Cistrome Factor Overlap and Target gene

Human Immunodeficiency Viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. In most cases, HIV is a sexually transmitted infection and occurs by contact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids.
Size: ～9181 nucleotides [RefSeq: NC_001802]
Encoding: RT, PR, IN, Nef and so on
Human Disease: Infection with HIV can lead to HIV/AIDS, AIDS-associated lymphoma, etc. Click here to see all HIV associated human diseases
Drug: The long-term efficacy of drug can induce the emergence of drug resistant virus mutants, some common antiviral drug such as lamivudine, zidovudine, tenofovir, telbivudine, darunavir, raltegravir, enfuvirtide, efavirenz, stavudine, nelfinavir can produce HIV mutants RT.M184V, RT.K103N, RT.K101E, PR.M46I, IN.T97A, etc. Click here to see more HIV drug resistance mutations.


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The cistrome refers to "the set of cis-acting targets of a trans-acting factor on a genome-wide scale."