Overview of HIV Mutation, Integration-Cistrome Factor Overlap and Target gene

Human Immunodeficiency Viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. In most cases, HIV is a sexually transmitted infection and occurs by contact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids.
Size: ～9181 nucleotides [RefSeq: NC_001802]
Encoding: RT, PR, IN, Nef and so on
Human Disease: Infection with HIV can lead to HIV/AIDS, AIDS-associated lymphoma, etc. Click here to see all HIV associated human diseases
Drug: The long-term efficacy of drug can induce the emergence of drug resistant virus mutants, some common antiviral drug such as lamivudine, zidovudine, tenofovir, telbivudine, darunavir, raltegravir, enfuvirtide, efavirenz, stavudine, nelfinavir can produce HIV mutants RT.M184V, RT.K103N, RT.K101E, PR.M46I, IN.T97A, etc. Click here to see more HIV drug resistance mutations.

Click the blue font on the page to view detailed information.
The cistrome refers to "the set of cis-acting targets of a trans-acting factor on a genome-wide scale."

HIV Mutation Info

Click here to see all HIV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	30714528	T215A	RT	D G R S CI C	View
2	30714528	T215Y	RT	D G R S CI C	View
3	30714528	T215F	RT	D G R S CI C	View
4	17311088	E98D	Nef	G R S I CI C	View
5	17311088	V82I	Gag	G R S I CI C	View
6	17311088	G79F	Gag	G R S I CI C	View
7	17311088	Y79F	Gag	G R S I CI C	View
8	28167814	G73S	PR	D G R S C	View
9	28167814	L10I	PR	D G R S C	View
10	30714528	M184V	RT	G R S CI C	View
11	30714528	D67N	RT	G R S CI C	View
12	30714528	M41L	RT	G R S CI C	View
13	32045455	K219R	RT	D G R S C	View
14	32045455	G190A	RT	D G R S C	View
15	32045455	M184I	RT	D G R S C	View
16	32045455	M184V	RT	D G R S C	View
17	32045455	Y181C	RT	D G R S C	View
18	32045455	V179D	RT	D G R S C	View
19	32045455	V179E	RT	D G R S C	View
20	32045455	V179T	RT	D G R S C	View
21	32045455	E138A	RT	D G R S C	View
22	32045455	E138G	RT	D G R S C	View
23	32045455	K103N	RT	D G R S C	View
24	32045455	A98G	RT	D G R S C	View
25	32045455	K65R	RT	D G R S C	View
26	32045455	I54V	PR	D G R S C	View
27	32045455	L33F	PR	D G R S C	View
28	31889319	S283G	IN	D G R S C	View
29	31889319	D278A	IN	D G R S C	View
30	31889319	A269K	IN	D G R S C	View
31	31889319	A265V	IN	D G R S C	View
32	31889319	L234I	IN	D G R S C	View
33	31889319	V201I	IN	D G R S C	View
34	31889319	D167E	IN	D G R S C	View
35	31889319	E157Q	IN	D G R S C	View
36	31889319	P142T	IN	D G R S C	View
37	31889319	K136Q	IN	D G R S C	View
38	31889319	T125A	IN	D G R S C	View
39	31889319	T124A	IN	D G R S C	View
40	31889319	L101I	IN	D G R S C	View
41	31889319	F100Y	IN	D G R S C	View
42	31889319	P90T	IN	D G R S C	View
43	31889319	L74I	IN	D G R S C	View
44	31889319	L74M	IN	D G R S C	View
45	31889319	V72I	IN	D G R S C	View
46	31889319	M50I	IN	D G R S C	View
47	31889319	V31I	IN	D G R S C	View
48	31889319	D25E	IN	D G R S C	View
49	31889319	K14R	IN	D G R S C	View
50	31889319	E11D	IN	D G R S C	View
51	31693887	H116N	Nef	G R S I C	View
52	31693887	K94E	Nef	G R S I C	View
53	32300784	M184V	RT	D G R S C	View
54	32300784	K65R	RT	D G R S C	View
55	32300784	V179E	RT	D G R S C	View
56	32300784	K103N	RT	D G R S C	View
57	32300784	Y181C	RT	D G R S C	View
58	32345262	V179D	RT	D G S CI C	View
59	32345262	K103R	RT	D G S CI C	View
60	32345262	V179E	RT	D G S CI C	View
61	32345262	Y181C	RT	D G S CI C	View
62	32345262	H221Y	RT	D G S CI C	View
63	32345262	E138A	RT	D G S CI C	View
64	32692778	M41L	RT	D G R S C	View
65	32692778	E44D	RT	D G R S C	View
66	32692778	K65R	RT	D G R S C	View
67	32692778	K70E	RT	D G R S C	View
68	32692778	M184I	RT	D G R S C	View
69	32692778	M184V	RT	D G R S C	View
70	32692778	K219R	RT	D G R S C	View
71	32692778	K103N	RT	D G R S C	View
72	32692778	E138A	RT	D G R S C	View
73	32692778	E138G	RT	D G R S C	View
74	32692778	V179E	RT	D G R S C	View
75	32692778	M230L	RT	D G R S C	View
76	32692778	K238T	RT	D G R S C	View
77	32692778	P225H	RT	D G R S C	View
78	32692778	Y188H	RT	D G R S C	View
79	32692778	T215Y	RT	D G R S C	View
80	15067030	A146P	Gag	G R S I C	View
81	17311088	R184K	Nef	G R S CI C	View
82	17311088	I147L	Gag	G R S CI C	View
83	17311088	A146P	Gag	G R S CI C	View
84	17311088	E93D	Gag	G R S CI C	View
85	17311088	R91G	Nef	G R S CI C	View
86	17311088	L87I	Nef	G R S CI C	View
87	17311088	V85L	Nef	G R S CI C	View
88	17311088	E62G	Gag	G R S CI C	View
89	17311088	E62A	Gag	G R S CI C	View
90	17311088	E62V	Gag	G R S CI C	View
91	17311088	A83G	Nef	G R S CI C	View
92	11581417	K340E	Env	G R S CI C	View
93	11581417	K350A	Env	G R S CI C	View
94	11581417	G429E	Env	G R S CI C	View
95	19005274	T215C	RT	D G R S C	View
96	19005274	T215D	RT	D G R S C	View
97	19005274	T215I	RT	D G R S C	View
98	19005274	T215F	RT	D G R S C	View
99	19005274	T215Y	RT	D G R S C	View
100	19005274	T215S	RT	D G R S C	View

HIV Overlap Info between Viral Integration Fragments and Cistrome Factors

Click to see statistics heatmap of VIS-Factor Overlap in the human genome of HIV

Click to see histogram of VIS-Factor Overlap by chromosome of HIV

Click to see the overlap count of three factors and HIV intergration fragments on the human chromosomes

Only show 100 info Click here to see all HIV Integration Sites

DVID	Chromosome	Histone Modification	Transcription Factor Binding Site	Chromatin Accessibility	Sum of Overlapped Records	Detail
4000003	chr1	1945	2399	1988	6332	View
4500020	chr1	3317	1850	1137	6304	View
4000024	chr1	2302	115	5	2422	View
4000044	chr1	1187	134	359	1680	View
4000049	chr1	1078	96	442	1616	View
4000072	chr1	1205	97	13	1315	View
4000079	chr1	430	382	448	1260	View
4000088	chr1	1162	11		1173	View
4000090	chr1	119	473	573	1165	View
4000094	chr1	932	66	146	1144	View
4000122	chr1	763	75	151	989	View
4000141	chr1	237	322	356	915	View
4000143	chr1	882	18		900	View
4000152	chr1	792	58	21	871	View
4000153	chr1	700	81	84	865	View
4000155	chr1	855	5	2	862	View
4000179	chr1	664	101	46	811	View
4000196	chr1	75	432	253	760	View
4000199	chr1	594	67	94	755	View
4000201	chr1	498	132	122	752	View
4000231	chr1	106	505	73	684	View
4000245	chr1	560	18	73	651	View
4000246	chr1	33	271	347	651	View
4000255	chr1	430	123	84	637	View
4000259	chr1	252	205	176	633	View
4000262	chr1	202	280	144	626	View
4000284	chr1	7	489	96	592	View
4000291	chr1	170	322	89	581	View
4000295	chr1	190	208	177	575	View
4000305	chr1	334	149	78	561	View
4000329	chr1	409	66	55	530	View
4000333	chr1	231	174	124	529	View
4000360	chr1	477	33	8	518	View
4000363	chr1	259	98	158	515	View
4000385	chr1	347	97	54	498	View
4000414	chr1	11	426	45	482	View
4000426	chr1	170	140	161	471	View
4000438	chr1	449	11	3	463	View
4000452	chr1	257	125	72	454	View
4000461	chr1	409	31	7	447	View
4000472	chr1	392	31	15	438	View
4000488	chr1	410	9	10	429	View
4000504	chr1	379	29	8	416	View
4000513	chr1	172	56	179	407	View
4000514	chr1	321	66	20	407	View
4000518	chr1	59	129	216	404	View
4000534	chr1	318	48	23	389	View
4000549	chr1	121	74	192	387	View
4000556	chr1	254	51	68	373	View
4000570	chr1	228	123	14	365	View
4000577	chr1	329	33	1	363	View
4000595	chr1	144	39	176	359	View
4000608	chr1	327	14	3	344	View
4000609	chr1	237	23	83	343	View
4000618	chr1	44	277	20	341	View
4000639	chr1	317	18		335	View
4000653	chr1	5	230	96	331	View
4000659	chr1	313	14	1	328	View
4000688	chr1	191	47	79	317	View
4000693	chr1	108	80	127	315	View
4000695	chr1	81	155	78	314	View
4000709	chr1	291	16	2	309	View
4000714	chr1	178	32	97	307	View
4000722	chr1	142	148	13	303	View
4000734	chr1	102	136	61	299	View
4500019	chr1	83	122	85	290	View
4000765	chr1	177	35	75	287	View
4000788	chr1	123	146	15	284	View
4000781	chr1	58	103	122	283	View
4000784	chr1	270	13		283	View
4000807	chr1	77	61	138	276	View
4000808	chr1	75	101	99	275	View
4000824	chr1	143	93	36	272	View
4000837	chr1	265	3		268	View
4000842	chr1	29	221	17	267	View
4000869	chr1	190	37	34	261	View
4000872	chr1	44	92	124	260	View
4000877	chr1	246	8	3	257	View
4000879	chr1	194	54	8	256	View
4000898	chr1	222	31		253	View
4000900	chr1	231	21	1	253	View
4000901	chr1	168	73	12	253	View
4000913	chr1	192	40	19	251	View
4000905	chr1	234	11	5	250	View
4000938	chr1	67	82	96	245	View
4000941	chr1	61	88	94	243	View
4000942	chr1	41	140	61	242	View
4000946	chr1	9	215	17	241	View
4000967	chr1	4	47	186	237	View
4000971	chr1	207	11	19	237	View
4000975	chr1	127	62	47	236	View
4000985	chr1	181	50	1	232	View
4000986	chr1	94	40	98	232	View
4000994	chr1	144	80	6	230	View
4001005	chr1	11	130	89	230	View
4001010	chr1	115	81	33	229	View
4001026	chr1	145	43	40	228	View
4001053	chr1	92	51	81	224	View
4001069	chr1	38	163	20	221	View
4001079	chr1	83	64	71	218	View

HIV Target Gene Info

Click to see correlation between gene expression and proportions of infiltrating immune cells of HIV

ID	Target gene	Virus	Gene Function	Literature Count	Detail
1	PRKN	HIV	Suppressor gene	1	View
2	FBXO32	HIV	Suppressor gene	3	View
3	CHUK	HIV	Suppressor gene	3	View
4	DMTF1	HIV	Suppressor gene	1	View
5	ASXL1	HIV	Suppressor gene	3	View
6	RASSF3	HIV	Suppressor gene	2	View
7	GRIN2A	HIV	Suppressor gene	1	View
8	ANXA1	HIV	Suppressor gene	1	View
9	RASSF5	HIV	Suppressor gene	1	View
10	BLM	HIV	Suppressor gene	2	View
11	DAPK2	HIV	Suppressor gene	1	View
12	ING3	HIV	Suppressor gene	2	View
13	ING4	HIV	Suppressor gene	1	View
14	LATS1	HIV	Suppressor gene	1	View
15	CIC	HIV	Suppressor gene	1	View
16	ING5	HIV	Suppressor gene	2	View
17	ARHGEF12	HIV	Suppressor gene	1	View
18	HBP1	HIV	Suppressor gene	1	View
19	VPS53	HIV	Suppressor gene	1	View
20	CTNNA2	HIV	Suppressor gene	1	View
21	MCM9	HIV	Suppressor gene	1	View
22	RB1	HIV	Suppressor gene	2	View
23	CBX5	HIV	Suppressor gene	2	View
24	MAP2K4	HIV	Suppressor gene	2	View
25	SP100	HIV	Suppressor gene	1	View
26	CACNA2D3	HIV	Suppressor gene	1	View
27	RNF8	HIV	Suppressor gene	1	View
28	CTNNA3	HIV	Suppressor gene	1	View
29	PAFAH1B1	HIV	Suppressor gene	2	View
30	RB1CC1	HIV	Suppressor gene	1	View
31	CNTNAP2	HIV	Suppressor gene	2	View
32	WWOX	HIV	Suppressor gene	3	View
33	IFI16	HIV	Suppressor gene	1	View
34	USP12	HIV	Suppressor gene	1	View
35	FZR1	HIV	Suppressor gene	1	View
36	RAB7A	HIV	Suppressor gene	3	View
37	CIZ1	HIV	Suppressor gene	2	View
38	CCAR2	HIV	Suppressor gene	1	View
39	INPP4B	HIV	Suppressor gene	5	View
40	SYNPO2	HIV	Suppressor gene	1	View
41	SMYD4	HIV	Suppressor gene	1	View
42	FBXW7	HIV	Suppressor gene	3	View
43	EPB41	HIV	Suppressor gene	1	View
44	PTPN1	HIV	Suppressor gene	1	View
45	ACVR1C	HIV	Suppressor gene	1	View
46	XAF1	HIV	Suppressor gene	4	View
47	PIWIL2	HIV	Suppressor gene	1	View
48	TNFRSF10A	HIV	Suppressor gene	1	View
49	TNFRSF10B	HIV	Suppressor gene	1	View
50	PTPN12	HIV	Suppressor gene	1	View
51	DNAJA3	HIV	Suppressor gene	1	View
52	MDC1	HIV	Suppressor gene	2	View
53	PPP2CA	HIV	Suppressor gene	1	View
54	STRADA	HIV	Suppressor gene	2	View
55	PTPN13	HIV	Suppressor gene	2	View
56	ARID1A	HIV	Suppressor gene	5	View
57	DNAJB1	HIV	Suppressor gene	1	View
58	RBL1	HIV	Suppressor gene	4	View
59	MAP3K4	HIV	Suppressor gene	1	View
60	ATM	HIV	Suppressor gene	3	View
61	RBL2	HIV	Suppressor gene	2	View
62	ZDHHC2	HIV	Suppressor gene	1	View
63	PTPN2	HIV	Suppressor gene	1	View
64	ZNF292	HIV	Suppressor gene	2	View
65	ARID2	HIV	Suppressor gene	2	View
66	ANAPC1	HIV	Suppressor gene	1	View
67	KDM3A	HIV	Suppressor gene	2	View
68	KDM3B	HIV	Suppressor gene	1	View
69	PTPN23	HIV	Suppressor gene	2	View
70	SSBP2	HIV	Suppressor gene	1	View
71	CLDN1	HIV	Suppressor gene	1	View
72	INTS6	HIV	Suppressor gene	2	View
73	PPP2R5C	HIV	Suppressor gene	3	View
74	RACK1	HIV	Suppressor gene	1	View
75	DNAJC11	HIV	Suppressor gene	1	View
76	EPHA1	HIV	Suppressor gene	1	View
77	CDKN2C	HIV	Suppressor gene	1	View
78	CUL1	HIV	Suppressor gene	1	View
79	IFT88	HIV	Suppressor gene	1	View
80	APAF1	HIV	Suppressor gene	1	View
81	PPP3CC	HIV	Suppressor gene	2	View
82	PTPRC	HIV	Suppressor gene	1	View
83	TGFBR2	HIV	Suppressor gene	3	View
84	RAD23B	HIV	Suppressor gene	1	View
85	SLC9A3R1	HIV	Suppressor gene	2	View
86	HOPX	HIV	Suppressor gene	1	View
87	KDM5A	HIV	Suppressor gene	2	View
88	PTPRD	HIV	Suppressor gene	1	View
89	TGFBR3	HIV	Suppressor gene	2	View
90	PDCD4	HIV	Suppressor gene	1	View
91	GGNBP2	HIV	Suppressor gene	2	View
92	PKNOX1	HIV	Suppressor gene	1	View
93	XPO5	HIV	Suppressor gene	1	View
94	KDM6A	HIV	Suppressor gene	3	View
95	NOL7	HIV	Suppressor gene	1	View
96	CFTR	HIV	Suppressor gene	1	View
97	PHACTR4	HIV	Suppressor gene	4	View
98	BASP1	HIV	Suppressor gene	1	View
99	RAD51C	HIV	Suppressor gene	1	View
100	GSK3B	HIV	Suppressor gene	1	View


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