Overview of HBV Mutation, Integration-Cistrome Factor Overlap and Target gene

Hepatitis B virus (HBV) is a partially double-stranded DNA virus, a species of the genus Orthohepadnavirus and a member of the Hepadnaviridae family of viruses.
Size: 3020–3320 nucleotides long (for the full length strand) and 1700–2800 nucleotides long (for the short length strand) [RefSeq: NC_003977.1]
Encoding: S, X, C, P, BCP
Human Disease: Infection with HBV can lead to Chronic hepatitis B, Liver cirrhosis, Hepatocellular carcinoma, etc. Click here to see all HBV associated human diseases
Drug: The long-term efficacy of drug can induce the emergence of drug resistant virus mutants, some common antiviral drug such as lamivudine, entecavir, tenofovir, telbivudine, adefovir, rituximab, ganciclovir can produce HBV mutants rtM204I, rtL180M/rtM204V, sT118K, xK130M, etc. Click here to see more HBV RT drug resistance mutations.

Click the blue font on the page to view detailed information.
The cistrome refers to "the set of cis-acting targets of a trans-acting factor on a genome-wide scale".

HBV Mutation Info

Click here to see all HBV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	33446224	M204I	RT	D G R S CI C	View
2	33446224	M204V	RT	D G R S CI C	View
3	33446224	S202I	RT	D G R S CI C	View
4	33446224	L180M	RT	D G R S CI C	View
5	33446224	V173L	RT	D G R S CI C	View
6	29016603	W156*	S	G R S I CI C	View
7	29016603	G145R	S	G R S I CI C	View
8	28658511	G145R	S	D G R S I C	View
9	29016603	L109R	S	G R S CI C	View
10	29016603	G130E	S	G R S CI C	View
11	28582431	T131N	S	G R S I C	View
12	28582431	T126I	S	G R S I C	View
13	28582431	S143L	S	G R S I C	View
14	28582431	R122K	S	G R S I C	View
15	28582431	P120S	S	G R S I C	View
16	28582431	A128V	S	G R S I C	View
17	28500726	M204V	RT	D G R S C	View
18	28500726	M204I	RT	D G R S C	View
19	28500726	L80V	RT	D G R S C	View
20	28500726	L80I	RT	D G R S C	View
21	28500726	L180M	RT	D G R S C	View
22	28500726	A194T	RT	D G R S C	View
23	24637457	L80*	RT	D G R S C	View
24	24637457	I169N	RT	D G R S C	View
25	24637457	V173L	RT	D G R S C	View
26	24637457	L180*	RT	D G R S C	View
27	24637457	A181G	RT	D G R S C	View
28	24637457	S202I	RT	D G R S C	View
29	24637457	M204V	RT	D G R S C	View
30	24637457	Q215S	RT	D G R S C	View
31	24637457	I233V	RT	D G R S C	View
32	24637457	N236I	RT	D G R S C	View
33	24637457	M250V	RT	D G R S C	View
34	22459735	D144E	S	G R S I C	View
35	22459735	K122R	S	G R S I C	View
36	23029487	G1862T	PreC	G R S CI C	View
37	27882062	T125M	S	G R S I C	View
38	27882062	S143L	S	G R S I C	View
39	27882062	S117G	S	G R S I C	View
40	27882062	Q129H	S	G R S I C	View
41	27882062	P127T	S	G R S I C	View
42	27882062	P127L	S	G R S I C	View
43	27882062	E164D	S	G R S I C	View
44	27882062	D144E	S	G R S I C	View
45	27624502	G145R	S	G R S I C	View
46	23710315	A181V	RT	D G R CI C	View
47	23710315	S202G	RT	D G R CI C	View
48	25503289	A616G	S	G R S I C	View
49	25503289	T115T	S	G R S I C	View
50	25503289	S113S	S	G R S I C	View
51	25503289	Q101Q	S	G R S I C	View
52	25503289	L213F	S	G R S I C	View
53	25503289	L213I	S	G R S I C	View
54	25503289	S210R	S	G R S I C	View
55	25503289	S207N	S	G R S I C	View
56	25503289	Y206L	S	G R S I C	View
57	25503289	S204R	S	G R S I C	View
58	25503289	Y200F	S	G R S I C	View
59	25503289	T189I	S	G R S I C	View
60	25503289	S143T	S	G R S I C	View
61	25503289	Y134F	S	G R S I C	View
62	25503289	P127S	S	G R S I C	View
63	25503289	T126S	S	G R S I C	View
64	25503289	I110L	S	G R S I C	View
65	25503289	I92T	S	G R S I C	View
66	25503289	I86F	S	G R S I C	View
67	25503289	T779G	S	G R S I C	View
68	25503289	A994C	RT	G R S I C	View
69	25503289	A987C	RT	G R S I C	View
70	25503289	G933A	RT	G R S I C	View
71	25503289	A903G	RT	G R S I C	View
72	25503289	C885T	RT	G R S I C	View
73	25503289	A952G	RT	G R S I C	View
74	25503289	A886G	RT	G R S I C	View
75	25503289	G779T	RT	G R S I C	View
76	25503289	A436G	RT	G R S I C	View
77	25503289	C406T	RT	G R S I C	View
78	25503289	G852A	RT	G R S I C	View
79	25503289	C987A	RT	G R S I C	View
80	25503289	C987T	RT	G R S I C	View
81	25503289	C987G	RT	G R S I C	View
82	25503289	G969A	RT	G R S I C	View
83	25503289	G909A	RT	G R S I C	View
84	25503289	T907C	RT	G R S I C	View
85	25503289	T907A	RT	G R S I C	View
86	25503289	A906C	RT	G R S I C	View
87	25503289	C888A	RT	G R S I C	View
88	25503289	A853C	RT	G R S I C	View
89	25503289	T1055A	RT	G R S I C	View
90	25503289	A965C	RT	G R S I C	View
91	25503289	G950A	RT	G R S I C	View
92	25503289	T926A	RT	G R S I C	View
93	25503289	T926G	RT	G R S I C	View
94	25503289	T918A	RT	G R S I C	View
95	25503289	T895A	RT	G R S I C	View
96	25503289	A871C	RT	G R S I C	View
97	25503289	C823A	RT	G R S I C	View
98	25503289	A793T	RT	G R S I C	View
99	25503289	A533T	RT	G R S I C	View
100	25503289	A533C	RT	G R S I C	View

HBV Overlap Info between Viral Integration Fragments and Cistrome Factors

Click to see statistics heatmap of VIS-Factor Overlap in the human genome of HBV

Click to see histogram of VIS-Factor Overlap by chromosome of HBV

Click to see the overlap count of three factors and HBV intergration fragments on the human chromosomes

Only show 100 info Click here to see all HBV Integration Sites

DVID	Chromosome	Histone Modification	Transcription Factor Binding Site	Chromatin Accessibility	Sum of Overlapped Records	Detail
1000073	chr1	3509	2700	1838	8047	View
1000076	chr1	3495	2669	1854	8018	View
1000088	chr1	3994	2368	1161	7523	View
1000415	chr1	2271	2852	1118	6241	View
1400295	chr1	2468	2003	1662	6133	View
1501958	chr1	4160	1190	317	5667	View
1000138	chr1	4202	883	568	5653	View
1404541	chr1	432	3471	1636	5539	View
1508172	chr1	2888	1425	1032	5345	View
1000163	chr1	2078	1860	1074	5012	View
1000174	chr1	4024	612	260	4896	View
1501184	chr1	3505	473	585	4563	View
1000197	chr1	2385	1590	364	4339	View
1000198	chr1	3401	340	574	4315	View
1405440	chr1	3388	338	574	4300	View
1000209	chr1	2684	801	599	4084	View
1000229	chr1	2334	814	631	3779	View
1000234	chr1	2871	498	345	3714	View
1000238	chr1	345	1620	1629	3594	View
1000248	chr1	296	1618	1624	3538	View
1000254	chr1	3373	52	9	3434	View
1000259	chr1	3236	135	4	3375	View
1503157	chr1	2658	313	323	3294	View
1000269	chr1	2682	246	327	3255	View
1000310	chr1	1679	925	647	3251	View
1405200	chr1	2669	241	326	3236	View
1000280	chr1	819	1923	397	3139	View
1000464	chr1	1586	1058	492	3136	View
1000281	chr1	2639	298	175	3112	View
1404588	chr1	1845	620	499	2964	View
1503403	chr1	82	1581	1295	2958	View
1404363	chr1	2142	351	362	2855	View
1000325	chr1	633	1810	391	2834	View
1501727	chr1	43	1717	1068	2828	View
1000326	chr1	650	1821	355	2826	View
1000327	chr1	648	1822	355	2825	View
1405142	chr1	2121	343	349	2813	View
1000331	chr1	642	1814	355	2811	View
1000334	chr1	637	1812	357	2806	View
1000335	chr1	635	1806	362	2803	View
1000336	chr1	630	1802	366	2798	View
1000337	chr1	630	1801	366	2797	View
1405039	chr1	575	1750	363	2688	View
1000357	chr1	718	1742	203	2663	View
1000359	chr1	628	1764	268	2660	View
1405033	chr1	625	1762	270	2657	View
1000362	chr1	686	1747	219	2652	View
1000364	chr1	714	1737	200	2651	View
1000372	chr1	711	1729	191	2631	View
1000374	chr1	709	1724	189	2622	View
1000375	chr1	600	1746	270	2616	View
1000377	chr1	703	1714	188	2605	View
1000392	chr1	685	1688	165	2538	View
1000396	chr1	684	1684	145	2513	View
1000405	chr1	680	1672	134	2486	View
1000406	chr1	498	1638	346	2482	View
1000409	chr1	491	1619	331	2441	View
1000413	chr1	665	1639	125	2429	View
1000414	chr1	489	1614	326	2429	View
1506591	chr1	260	1111	1035	2406	View
1000422	chr1	2123	201	47	2371	View
1000423	chr1	1647	498	220	2365	View
1000433	chr1	60	1240	1041	2341	View
1000444	chr1	464	1550	274	2288	View
1000450	chr1	455	1524	273	2252	View
1000451	chr1	455	1521	273	2249	View
1000467	chr1	2098	34		2132	View
1000486	chr1	435	1400	261	2096	View
1000491	chr1	1843	99	136	2078	View
1507122	chr1	264	891	818	1973	View
1000537	chr1	541	1324	97	1962	View
1000581	chr1	372	1225	260	1857	View
1000590	chr1	513	1236	91	1840	View
1000614	chr1	1728	35	27	1790	View
1000640	chr1	507	528	683	1718	View
1000646	chr1	330	1114	257	1701	View
1000648	chr1	329	1110	257	1696	View
1000649	chr1	327	1110	256	1693	View
1000667	chr1	1601	29	6	1636	View
1000682	chr1	298	1062	250	1610	View
1000689	chr1	459	1063	77	1599	View
1000702	chr1	274	1092	211	1577	View
1000703	chr1	274	1091	212	1577	View
1000708	chr1	273	1092	210	1575	View
1000709	chr1	273	1086	211	1570	View
1000710	chr1	286	1037	246	1569	View
1000711	chr1	272	1091	205	1568	View
1000718	chr1	701	598	262	1561	View
1000722	chr1	283	1024	245	1552	View
1000723	chr1	267	1073	211	1551	View
1000734	chr1	267	1071	211	1549	View
1000737	chr1	265	1071	211	1547	View
1505857	chr1	705	688	144	1537	View
1000739	chr1	260	1068	207	1535	View
1506481	chr1	580	481	467	1528	View
1000744	chr1	260	1064	202	1526	View
1000746	chr1	260	1063	202	1525	View
1000752	chr1	269	996	243	1508	View
1000756	chr1	268	993	243	1504	View
1000758	chr1	439	986	74	1499	View

HBV Target Gene Info

Click to see correlation between gene expression and proportions of infiltrating immune cells of HBV

Only show 100 info Click here to see all HBV Target Gene

ID	Target gene	Virus	Gene Function	Literature Count	Detail
1	SRGAP3	HBV	Suppressor gene	2	View
2	WWOX	HBV	Suppressor gene	10	View
3	SH2B3	HBV	Suppressor gene	2	View
4	TFAP2A	HBV	Suppressor gene	1	View
5	TNFRSF10A	HBV	Suppressor gene	1	View
6	RNF8	HBV	Suppressor gene	1	View
7	ZHX2	HBV	Suppressor gene	2	View
8	UIMC1	HBV	Suppressor gene	1	View
9	TNFAIP3	HBV	Suppressor gene	1	View
10	TSLP	HBV	Suppressor gene	1	View
11	SMAD2	HBV	Suppressor gene	1	View
12	TMPRSS6	HBV	Suppressor gene	1	View
13	TGFBI	HBV	Suppressor gene	1	View
14	TGFBR2	HBV	Suppressor gene	2	View
15	TGFBR3	HBV	Suppressor gene	2	View
16	TSC22D1	HBV	Suppressor gene	1	View
17	UBE4B	HBV	Suppressor gene	4	View
18	ROBO1	HBV	Suppressor gene	2	View
19	TSC2	HBV	Suppressor gene	1	View
20	ZMYND11	HBV	Suppressor gene	1	View
21	SMARCA2	HBV	Suppressor gene	1	View
22	UNC5A	HBV	Suppressor gene	2	View
23	UNC5C	HBV	Suppressor gene	2	View
24	UNC5D	HBV	Suppressor gene	6	View
25	ZFHX3	HBV	Suppressor gene	3	View
26	SMARCA4	HBV	Suppressor gene	1	View
27	SASH1	HBV	Suppressor gene	5	View
28	TCF7L2	HBV	Suppressor gene	2	View
29	SIAH1	HBV	Suppressor gene	1	View
30	TCF4	HBV	Suppressor gene	1	View
31	SAMD9L	HBV	Suppressor gene	1	View
32	ZNF185	HBV	Suppressor gene	1	View
33	SLC5A8	HBV	Suppressor gene	2	View
34	SMARCB1	HBV	Suppressor gene	1	View
35	RPA1	HBV	Suppressor gene	1	View
36	SMARCC1	HBV	Suppressor gene	2	View
37	THRB	HBV	Suppressor gene	8	View
38	SSBP2	HBV	Suppressor gene	1	View
39	XRCC5	HBV	Suppressor gene	1	View
40	SAFB2	HBV	Suppressor gene	1	View
41	RPL11	HBV	Suppressor gene	1	View
42	SAFB	HBV	Suppressor gene	2	View
43	WNT11	HBV	Suppressor gene	1	View
44	TOM1L2	HBV	Suppressor gene	2	View
45	WNK2	HBV	Suppressor gene	1	View
46	SETD2	HBV	Suppressor gene	1	View
47	SH3GLB1	HBV	Suppressor gene	1	View
48	ST13	HBV	Suppressor gene	1	View
49	SOD2	HBV	Suppressor gene	1	View
50	TPTE2	HBV	Suppressor gene	3	View
51	USP33	HBV	Suppressor gene	1	View
52	STK10	HBV	Suppressor gene	2	View
53	SPTBN1	HBV	Suppressor gene	1	View
54	ZNF292	HBV	Suppressor gene	1	View
55	RUNX2	HBV	Suppressor gene	1	View
56	SEMA3F	HBV	Suppressor gene	2	View
57	ST7	HBV	Suppressor gene	1	View
58	TRIM3	HBV	Suppressor gene	1	View
59	TAGLN	HBV	Suppressor gene	1	View
60	TWIST2	HBV	Suppressor gene	1	View
61	TRIM35	HBV	Suppressor gene	1	View
62	TP53	HBV	Suppressor gene	11	View
63	TP53BP2	HBV	Suppressor gene	1	View
64	TMEFF1	HBV	Suppressor gene	2	View
65	TMEFF2	HBV	Suppressor gene	3	View
66	STAT1	HBV	Suppressor gene	3	View
67	ZBTB7C	HBV	Suppressor gene	2	View
68	SHISA3	HBV	Suppressor gene	1	View
69	STARD13	HBV	Suppressor gene	5	View
70	VHL	HBV	Suppressor gene	1	View
71	MAP2K4	HBV	Suppressor gene	1	View
72	PRKN	HBV	Suppressor gene	4	View
73	PAX5	HBV	Suppressor gene	1	View
74	PRKCB	HBV	Suppressor gene	1	View
75	LRIG1	HBV	Suppressor gene	1	View
76	PRKAA2	HBV	Suppressor gene	2	View
77	LRP1B	HBV	Suppressor gene	5	View
78	MME	HBV	Suppressor gene	1	View
79	PACRG	HBV	Suppressor gene	1	View
80	PCDH9	HBV	Suppressor gene	7	View
81	PPP3CC	HBV	Suppressor gene	1	View
82	PPP2R5C	HBV	Suppressor gene	3	View
83	PPP2R2C	HBV	Suppressor gene	4	View
84	LSAMP	HBV	Suppressor gene	3	View
85	PTEN	HBV	Suppressor gene	1	View
86	PPP2CB	HBV	Suppressor gene	1	View
87	PPP2CA	HBV	Suppressor gene	1	View
88	PTPN12	HBV	Suppressor gene	1	View
89	PTPN2	HBV	Suppressor gene	1	View
90	MTSS1	HBV	Suppressor gene	1	View
91	PTPRD	HBV	Suppressor gene	8	View
92	OSGIN1	HBV	Suppressor gene	1	View
93	PTPRJ	HBV	Suppressor gene	3	View
94	PTPRK	HBV	Suppressor gene	2	View
95	OSCP1	HBV	Suppressor gene	2	View
96	PTPRT	HBV	Suppressor gene	3	View
97	LXN	HBV	Suppressor gene	1	View
98	PPM1L	HBV	Suppressor gene	2	View
99	POU6F2	HBV	Suppressor gene	1	View
100	MAD1L1	HBV	Suppressor gene	1	View


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