|
Mutation Information
|
Mutation Site
|
M46I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Genotype/Subtype
|
CRF07_BC;B |
|
Viral Reference
|
AF503396;
JF906665;
HQ215583;
JQ901027;
JQ901094;
EF122515;
AY008714;
U51189;
JF906597;
JQ028206;
AF286229;
AY008717;
K03455;
U71182;
KF857447;
AY358072;
KC183783;
X52154 |
|
Relevant Drug
|
atazanavir (ATV);fosamprenavir (FPV);indinavir (IDV);lopinavir (LPV);saquinavir (SQV);nelfinavir (NFV);tipranavir (TPV);efavirenz (EFV);etravirine(ETR);rilpivirine (RPV);nevirapine (NPV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
28622345
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2017 |
|
Journal
|
PloS one |
|
Title
|
The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014. |
|
Author
|
Zeng P,Liu Y,He M,Wang J,Keating S,Mao W,Huang M,Ma H,He W,Bi X,Liao D,Busch M,Ness P,Liu J,Shan H,NHLBI Recipient Epidemiology and Donor Evaluation Study-III program. |
|
Evidence
|
31 DRMs were identified from 27 samples including four protease inhibitors (PIs) accessory DRMs, two PIs major DRMs (M46I), two nucleoside RT inhibitors DRMs (K219R and K70Q), and 23 nonnucleoside RT inhibitors DRMs.
|
|
|
HIV Mutation Detail Information