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Mutation Information
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Mutation Site
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V179D |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Genotype/Subtype
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CRF07_BC;CRF01B;CRF08_BC;B |
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Viral Reference
|
AF503396;
JF906665;
HQ215583;
JQ901027;
JQ901094;
EF122515;
AY008714;
U51189;
JF906597;
JQ028206;
AF286229;
AY008717;
K03455;
U71182;
KF857447;
AY358072;
KC183783;
X52154 |
|
Relevant Drug
|
zidovudine (AZT);stavudine (D4T);efavirenz (EFV);nevirapine (NPV);etravirine(ETR);rilpivirine (RPV);emtricitabine (FTC);lamivudine (LAM);abacavir (ABC);didanosine (DDI);emtricitabine (FTC);tenofovir (TDF);atazanavir (ATV);fosamprenavir (FPV);indinavir (IDV);lopinavir (LPV);saquinavir (SQV);tipranavir (TPV);nelfinavir (NFV) |
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Country
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China |
Literature Information
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PubMed PMID
|
28622345
|
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Disease
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HIV infection/AIDS
|
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Published Year
|
2017 |
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Journal
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PloS one |
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Title
|
The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014. |
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Author
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Zeng P,Liu Y,He M,Wang J,Keating S,Mao W,Huang M,Ma H,He W,Bi X,Liao D,Busch M,Ness P,Liu J,Shan H,NHLBI Recipient Epidemiology and Donor Evaluation Study-III program. |
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Evidence
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For example, 16 of 27 donors showed PLLR (or above) to NNRTI due to V179D/E mutations; three donors with mutations of E138A were found to have PLLR to etravirine (ETR) and low-level resistance (LLR) to rilpivirine (RPV).
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HIV Mutation Detail Information