|
Mutation Information
|
Mutation Site
|
L74M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Combined Mutation
|
in.S147G+in.G140S+in.L74M;in.S147G+in.E138K+in.L74M;in.Q148K+in.S147G+in.G140S+in.L74M;in.R263K+in.Q148R+in.E138K+in.L74M |
|
Genotype/Subtype
|
B;AG |
|
Viral Reference
|
AF324493.2;
AF096341.1 |
|
Relevant Drug
|
cabotegravir (CAB);raltegravir (RAL);elvitegravir (EVG);bictegravir (BIC);dolutegravir (DTG) |
|
Country
|
Canada |
Literature Information
|
PubMed PMID
|
30119633
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
|
Journal
|
Retrovirology |
|
Title
|
Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir. |
|
Author
|
Oliveira M,Ibanescu RI,Anstett K,Mésplède T,Routy JP,Robbins MA,Brenner BG,Montreal Primary HIV (PHI) Cohort Study Group. |
|
Evidence
|
One EVG-resistant variant (T66I) acquired L74M/G140S/S147G, L74M/E138K/S147G and H51Y with DTG CAB and BIC, respectively.
|
|
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HIV Mutation Detail Information