|
Mutation Information
|
Mutation Site
|
Y79F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
|
Combined Mutation
|
gag.Y79F+gag.E62A |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Immune Escape
|
Y |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
17311088
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2007 |
|
Journal
|
PloS one |
|
Title
|
Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape. |
|
Author
|
Karlsson AC,Iversen AK,Chapman JM,de Oliviera T,Spotts G,McMichael AJ,Davenport MP,Hecht FM,Nixon DF |
|
Evidence
|
We detected an HLA-A2-restricted CTL response against the major autologous, Gag SL9 epitope variant 77SLYNTIATL85 (82I) by week 39, and by week 63 several clones had developed an additional Y79F mutation in position three of the epitope (77SLFNTIATL85).
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HIV Mutation Detail Information