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Mutation Information
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Mutation Site
|
Q58E |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Genotype/Subtype
|
CRF07_BC |
|
Viral Reference
|
AF503396;
JF906665;
HQ215583;
JQ901027;
JQ901094;
EF122515;
AY008714;
U51189;
JF906597;
JQ028206;
AF286229;
AY008717;
K03455;
U71182;
KF857447;
AY358072;
KC183783;
X52154 |
|
Relevant Drug
|
nelfinavir (NFV);tipranavir (TPV) |
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Country
|
China |
Literature Information
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PubMed PMID
|
28622345
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2017 |
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Journal
|
PloS one |
|
Title
|
The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014. |
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Author
|
Zeng P,Liu Y,He M,Wang J,Keating S,Mao W,Huang M,Ma H,He W,Bi X,Liao D,Busch M,Ness P,Liu J,Shan H,NHLBI Recipient Epidemiology and Donor Evaluation Study-III program. |
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Evidence
|
Six protease inhibitors (PIs) DRMs were observed including, four PIs accessory DRMs: L23I (n = 1), K43T (n = 1) and Q58E (n = 2); and two PIs major DRMs: M46I. 3) Two nucleotide reverse transcriptase inhibitors (NRTIs) DRMs were: K219R and K70Q.
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HIV Mutation Detail Information