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Overview of XMRV Mutation, Integration-Cistrome Factor Overlap and Target gene


Xenotropic Murine Leukemia Virus-Related Virus (XMRV) is a retrovirus which was first described in 2006 as an apparently novel human pathogen found in tissue samples from men with prostate cancer. XMRV is a murine leukemia virus (MLV) that belongs to the virus family Retroviridae and the genus gammaretrovirus and have a single-stranded RNA genome that replicates through a DNA intermediate.
Size: ～8185 nucleotides [RefSeq: DQ399707.1]
 Encoding: RT
Human Disease: Prostate cancer, Oral squamous cell carcinoma, etc. Click here to see all XMRV associated human diseases

Click the blue font on the page to view detailed information.
The cistrome refers to "the set of cis-acting targets of a trans-acting factor on a genome-wide scale."



XMRV Mutation Info
Click here to see all XMRV Mutation Sites
ID PMID Mutation Gene/Protein/Region Description Detail
1 21908397 K103R
RT
D
R
 View
2 21908397 Q190M
RT
D
R
 View

XMRV Overlap Info between Viral Integration Fragments and Cistrome Factors

Click to see statistics heatmap of VIS-Factor Overlap in the human genome of XMRV

Click to see histogram of VIS-Factor Overlap by chromosome of XMRV

Click to see the overlap count of three factors and XMRV intergration fragments on the human chromosomes

 Click here to see all XMRV Integration Sites
DVID Chromosome Histone Modification Transcription Factor Binding Site Chromatin Accessibility Sum of Overlapped Records Detail
8100001 chr1 3008 3673 1779 8460 View
8100028 chr1 2407 616 127 3150 View
8100003 chr1 1313 203 19 1535 View
8100009 chr1 567 469 161 1197 View
8000006 chr1 316 17 19 352 View
8000015 chr1 26 12 38 View
8000018 chr1 21 6 27 View
8000028 chr1 0 View

XMRV Target Gene Info
Click here to see all XMRV Target Gene
ID Target gene Virus Type Literature Count Description Detail
1 SIRT4 XMRV Suppressor gene 1 View
2 DAPK3 XMRV Suppressor gene 1 View
3 TES XMRV Suppressor gene 1 View
4 H19 XMRV Oncogene & Suppressor gene 1 View
5 MIR483 XMRV Oncogene & Suppressor gene 1 View
6 STAT3 XMRV Oncogene & Suppressor gene 1 View
7 MET XMRV Oncogene 1 View
8 RERE XMRV Oncogene 1 View
9 TKTL1 XMRV Oncogene 1 View
10 MIR612 XMRV 1 View
11 MIR936 XMRV 1 View
12 MIR3190 XMRV 1 View
13 NAMPT XMRV 1 View
14 NFATC3 XMRV 1 View
15 MIR1256 XMRV 1 View
16 OSBPL2 XMRV 1 View
17 P3H4 XMRV 1 View
18 PIK3C2B XMRV 1 View
19 PRSS55 XMRV 1 View
20 RAD23A XMRV 1 View
21 SAP30BP XMRV 1 View
22 RBPJ XMRV 1 View
23 RC3H1 XMRV 1 View
24 RPLP0 XMRV 1 View
25 LINC02593 XMRV 1 View
26 SCGB1A1 XMRV 1 View
27 SCMH1 XMRV 1 View
28 SFR1 XMRV 1 View
29 SLK XMRV 1 View
30 SMIM20 XMRV 1 View
31 SNORA75 XMRV 1 View
32 SNORD37 XMRV 1 View
33 ST7-OT4 XMRV 1 View
34 TANGO6 XMRV 1 View
35 TFEC XMRV 1 View
36 TXN2 XMRV 1 View
37 WDR91 XMRV 1 View
38 ZDHHC18 XMRV 1 View
39 CCDC9 XMRV 1 View
40 EMD XMRV 1 View
41 EIF4G1 XMRV 1 View
42 EEF1G XMRV 1 View
43 EDN2 XMRV 1 View
44 ECE2 XMRV 1 View
45 DDIT4 XMRV 1 View
46 CYREN XMRV 1 View
47 CREB5 XMRV 1 View
48 COPZ2 XMRV 1 View
49 ENO1-AS1 XMRV 1 View
50 CCDC71L XMRV 1 View
51 CBX1 XMRV 1 View
52 CAV2 XMRV 1 View
53 CAPZA2 XMRV 1 View
54 B3GNT7 XMRV 1 View
55 ATP6V0A1 XMRV 1 View
56 APPBP2 XMRV 1 View
57 APP XMRV 1 View
58 GPN2 XMRV 1 View
59 APOL1 XMRV 1 View
60 LCAT XMRV 1 View
61 LAMA5 XMRV 1 View
62 KRT71 XMRV 1 View
63 KRT6A XMRV 1 View
64 ICE2 XMRV 1 View
65 HAP1 XMRV 1 View
66 GPR52 XMRV 1 View
67 LINC02915 XMRV 1 View
68 GCA XMRV 1 View
69 GALK1 XMRV 1 View
70 FSIP1 XMRV 1 View
71 FRMD8 XMRV 1 View
72 FOXB1 XMRV 1 View
73 FIGN XMRV 1 View
74 FARSA XMRV 1 View
75 FAM41C XMRV 1 View

Copyright © 2021.Tongji University, Life Science and Technology Department, Xiaoyan Zhang Lab.