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Mutation Information
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Mutation Site
|
E138E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
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Genotype/Subtype
|
B |
|
Viral Reference
|
AF324493.2;
AF096341.1 |
|
Relevant Drug
|
elvitegravir (EVG);cabotegravir (CAB);raltegravir (RAL);bictegravir (BIC);dolutegravir (DTG) |
|
Country
|
Canada |
Literature Information
|
PubMed PMID
|
30119633
|
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Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
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Journal
|
Retrovirology |
|
Title
|
Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir. |
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Author
|
Oliveira M,Ibanescu RI,Anstett K,Mésplède T,Routy JP,Robbins MA,Brenner BG,Montreal Primary HIV (PHI) Cohort Study Group. |
|
Evidence
|
The appearance of Q148R/Q95KQ followed by Q148R/Q95KQ/E138EK resistant strains at weeks 18 and 26 resulted in moderate 2.5- and 11.3-fold resistance to CAB, while retaining susceptibility to DTG and BIC.
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HIV Mutation Detail Information