Overview of MCV Mutation, Integration-Cistrome Factor Overlap and Target gene

Merkel cell polyomavirus (MCV or MCPyV) was first described in January 2008 in Pittsburgh, Pennsylvania. It was the first example of a human viral pathogen discovered using unbiased metagenomic next-generation sequencing with a technique called digital transcriptome subtraction. MCV is one of seven currently known human oncoviruses. It is suspected to cause the majority of cases of Merkel cell carcinoma, a rare but aggressive form of skin cancer. Approximately 80% of Merkel cell carcinoma (MCC) tumors have been found to be infected with MCV. MCV appears to be a common—if not universal—infection of older children and adults. It is found in respiratory secretions suggesting that it may be transmitted by a respiratory route. But it also can be found shedding from healthy skin, and in gastrointestinal tract tissues and elsewhere, and so its precise mode of transmission remains unknown.
Size: ～5387 nucleotides [RefSeq: EU375803]
Encoding: Large T, Small T, VP1, VP2, VP3
Human Disease: Merkel cell carcinoma.

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The cistrome refers to "the set of cis-acting targets of a trans-acting factor on a genome-wide scale."

MCV Mutation Info

Click here to see all MCV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	29696010	A20S	Small T	C	View
2	29696010	L114P	Small T	C	View
3	29696010	L142A	Small T	C	View
4	28461484	S220A	Large T	R	View
5	28461484	S239A	Large T	R	View
6	28461484	S147A	Large T	R	View
7	25631078	C109S	Small T	R	View
8	25631078	I122A	Small T	R	View
9	25631078	L126A	Small T	R	View
10	25631078	H130A	Small T	R	View
11	25631078	E146A	Small T	R	View
12	25631078	Y150A	Small T	R	View
13	25631078	K134A	Small T	R	View
14	25631078	R7A	Small T	R	View
15	25631078	K118A	Small T	R	View
16	25631078	L133A	Small T	R	View
17	25631078	L142A	Small T	R	View
18	23990782	M129L	VP2	R	View
19	23990782	M46A	VP2	R	View
20	23990782	M46D	VP2	R	View
21	23990782	M46I	VP2	R	View
22	23990782	M46N	VP2	R	View
23	23990782	M46V	VP2	R	View
24	23990782	M46X	VP2	R	View
25	22910713	W76A	VP1	R	View
26	22910713	K295A	VP1	R	View
27	22910713	S297N	VP1	R	View
28	22910713	Y81V	VP1	R	View
29	21841310	R7A	Small T	C	View
30	21841310	L142A	Small T	C	View
31	21841310	D44N	Small T	C	View
32	21501625	F391A	Large T	R	View
33	21501625	F391R	Large T	R	View
34	21501625	K331A	Large T	R	View
35	21501625	K331R	Large T	R	View
36	32962090	S220A	Large T	R	View
37	32962090	S239A	Large T	R	View
38	32962090	S147A	Large T	R	View
39	32962090	S142A	Large T	R	View
40	23954152	L142A	Small T		View
41	21454559	T205A	Large T		View
42	21454559	G207A	Large T		View
43	21454559	T208A	Large T		View
44	21454559	E216K	Large T		View
45	21454559	R204A	Large T		View
46	21454559	W209A	Large T		View
47	21454559	Y206A	Large T		View

MCV Overlap Info between Viral Integration Fragments and Cistrome Factors

Click here to see all MCV Integration Sites

DVID	Chromosome	Histone Modification	Transcription Factor Binding Site	Chromatin Accessibility	Sum of Overlapped Records	Detail
7000001	chr1	551	1257	85	1893	View
7300030	chr1	22	67	36	125	View
7000010	chr1	41	7		48	View
7000013	chr1	20	1	3	24	View
7300003	chr1	20	1	3	24	View
7300038	chr1		5		5	View

MCV Target Gene Info

ID	Target gene	Virus	Gene Function	Literature Count	Detail
1	DACH1	MCV	Suppressor gene	1	View
2	PTP4A2	MCV	Oncogene	1	View
3	BCL2L1	MCV	Oncogene	1	View
4	CBFA2T2	MCV		1	View
5	INPP5E	MCV		1	View
6	CDKAL1	MCV		2	View
7	DCAF7	MCV		1	View
8	LINC01994	MCV		1	View
9	PTPRG	MCV		1	View
10	CAMK2A	MCV		1	View
11	LUTZP2	MCV		1	View
12	KMT2D	MCV		1	View
13	LUZP2	MCV		1	View
14	TTC9C	MCV		1	View
15	FRG1	MCV		1	View
16	SF3B1	MCV		2	View
17	ECH1	MCV		1	View
18	BEST3	MCV		1	View
19	CASZ1	MCV		2	View
20	OFCC1	MCV		1	View