Overview of MCV Mutation, Integration-Cistrome Factor Overlap and Target gene

Merkel cell polyomavirus (MCV or MCPyV) was first described in January 2008 in Pittsburgh, Pennsylvania. It was the first example of a human viral pathogen discovered using unbiased metagenomic next-generation sequencing with a technique called digital transcriptome subtraction. MCV is one of seven currently known human oncoviruses. It is suspected to cause the majority of cases of Merkel cell carcinoma, a rare but aggressive form of skin cancer. Approximately 80% of Merkel cell carcinoma (MCC) tumors have been found to be infected with MCV. MCV appears to be a common—if not universal—infection of older children and adults. It is found in respiratory secretions suggesting that it may be transmitted by a respiratory route. But it also can be found shedding from healthy skin, and in gastrointestinal tract tissues and elsewhere, and so its precise mode of transmission remains unknown.
Size: ～5387 nucleotides [RefSeq: EU375803]
Encoding: Large T, Small T, VP1, VP2, VP3
Human Disease: Merkel cell carcinoma.

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The cistrome refers to "the set of cis-acting targets of a trans-acting factor on a genome-wide scale."

MCV Mutation Info

Click here to see all MCV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	21841310	L142A	Small T	C	View
2	23990782	M46I	VP2	R	View
3	23990782	M46N	VP2	R	View
4	23990782	M46V	VP2	R	View
5	29696010	A20S	Small T	C	View
6	22910713	W76A	VP1	R	View
7	22910713	K295A	VP1	R	View
8	22910713	S297N	VP1	R	View
9	22910713	Y81V	VP1	R	View
10	21841310	R7A	Small T	C	View
11	23990782	M46X	VP2	R	View
12	21841310	D44N	Small T	C	View
13	21501625	F391A	Large T	R	View
14	21501625	F391R	Large T	R	View
15	21501625	K331A	Large T	R	View
16	21501625	K331R	Large T	R	View
17	32962090	S220A	Large T	R	View
18	32962090	S239A	Large T	R	View
19	32962090	S147A	Large T	R	View
20	32962090	S142A	Large T	R	View
21	25631078	I122A	Small T	R	View
22	29696010	L114P	Small T	C	View
23	29696010	L142A	Small T	C	View
24	28461484	S220A	Large T	R	View
25	28461484	S239A	Large T	R	View
26	28461484	S147A	Large T	R	View
27	25631078	C109S	Small T	R	View
28	23990782	M46D	VP2	R	View
29	25631078	L126A	Small T	R	View
30	25631078	H130A	Small T	R	View
31	25631078	Y150A	Small T	R	View
32	23990782	M46A	VP2	R	View
33	23990782	M129L	VP2	R	View
34	25631078	L142A	Small T	R	View
35	25631078	L133A	Small T	R	View
36	25631078	K118A	Small T	R	View
37	25631078	R7A	Small T	R	View
38	25631078	K134A	Small T	R	View
39	25631078	E146A	Small T	R	View
40	21454559	T205A	Large T		View
41	21454559	G207A	Large T		View
42	21454559	T208A	Large T		View
43	21454559	E216K	Large T		View
44	21454559	R204A	Large T		View
45	21454559	W209A	Large T		View
46	21454559	Y206A	Large T		View
47	23954152	L142A	Small T		View

MCV Overlap Info between Viral Integration Fragments and Cistrome Factors

Click here to see all MCV Integration Sites

DVID	Chromosome	Histone Modification	Transcription Factor Binding Site	Chromatin Accessibility	Sum of Overlapped Records	Detail
7000001	chr1	551	1257	85	1893	View
7300030	chr1	22	67	36	125	View
7000010	chr1	41	7		48	View
7000013	chr1	20	1	3	24	View
7300003	chr1	20	1	3	24	View
7300038	chr1		5		5	View

MCV Target Gene Info

ID	Target gene	Virus	Gene Function	Literature Count	Detail
1	DACH1	MCV	Suppressor gene	1	View
2	BCL2L1	MCV	Oncogene	1	View
3	PTP4A2	MCV	Oncogene	1	View
4	TTC9C	MCV		1	View
5	SF3B1	MCV		2	View
6	PTPRG	MCV		1	View
7	OFCC1	MCV		1	View
8	LUZP2	MCV		1	View
9	LUTZP2	MCV		1	View
10	LINC01994	MCV		1	View
11	KMT2D	MCV		1	View
12	INPP5E	MCV		1	View
13	FRG1	MCV		1	View
14	ECH1	MCV		1	View
15	DCAF7	MCV		1	View
16	CDKAL1	MCV		2	View
17	CBFA2T2	MCV		1	View
18	CASZ1	MCV		2	View
19	CAMK2A	MCV		1	View
20	BEST3	MCV		1	View