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Mutation Information
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Mutation Site
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E138A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Combined Mutation
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rt.E138A+rt.V179D |
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Genotype/Subtype
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C |
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Relevant Drug
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NNRTIs |
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Country
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China |
Literature Information
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PubMed PMID
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32345262
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Clinical information
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Yes
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Disease
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HIV infection/AIDS
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Published Year
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2020 |
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Journal
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BMC infectious diseases |
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Title
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Natural presence of the V179D and K103R/V179D mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors in HIV-1 CRF65_cpx strains. |
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Author
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Liu Y,Zhang Y,Li H,Wang X,Jia L,Han J,Li T,Li J,Li L |
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Evidence
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The scale bar represents 0.5% genetic distance Accession number Subtype in the database Sex Risk factor Sampling year Geographic origin ART NNRTI resistance mutations MG706585 CRF65_cpx M MSM 2014 Hebei Treatment naive V179D KP698506 CRF65_cpx M NA 2011 NA Treatment naive V179D KT379558 C M MSM 2012 Guangdong Treatment naive V179D KR823099 C M MSM 2014 Beijing Treatment naive V179D JQ898223 CRF65_cpx M IDU 2009 Yunnan Treatment experienced V179D, Y181C, H221Y KR822879 C M MSM 2010 Beijing Treatment naive V179D MG706490 CRF65_cpx M MSM 2014 Hebei Treatment naive V179D KP250691 C M MSM 2009 Beijing Treatment naive V179D MG706508 CRF65_cpx M MSM 2014 Hebei Treatment naive V179D KP698505 CRF65_cpx M MSM 2010 Beijing Treatment naive V179D KP698503 CRF65_cpx M MSM 2010 Beijing Treatment naive V179D KX198586 CRF65_cpx M MSM 2013 Hebei Treatment naive K103R, V179D KF714341 C F HET 2009 Yunnan Treatment naive V179D KP698508 CRF65_cpx M MSM 2012 Beijing Treatment naive K103R, V179D KP698504 CRF65_cpx M MSM 2010 Beijing Treatment naive K103R, V179D KF714427 C M HET 2011 Yunnan Treatment naive V179D KR822921 C M MSM 2011 Beijing Treatment naive K103R, V179D KC183778 CRF65_cpx M MSM 2011 Anhui Treatment naive K103R, V179D KF714326 C M HET 2009 Yunnan Treatment naive V179D KP698507 CRF65_cpx M MSM 2012 Beijing Treatment naive V179D KY713419 C M MSM 2016 Beijing Treatment naive K103R, V179D KF714479 C F HET 2012 Yunnan Treatment naive V179D MH051841 CRF65_cpx M MSM 2015 Jilin Treatment naive K103R, V179D KF714310 C F HET 2009 Yunnan Treatment naive V179D KF714461 C F HET 2012 Yunnan Treatment naive E138A, V179D KC870030 CRF65_cpx M HET 2009 Yunnan Treatment naive V179D KC870027 CRF65_cpx F HET 2010 Yunnan Treatment naive V179D KF714363 C F HET 2010 Yunnan Treatment naive V179D MF941253 C NA NA 2014 Heilongjiang Treatment naive K103R, V179E KT625846 CRF65_cpx NA NA 2013 Yunnan Treatment naive V179D KC870028 CRF65_cpx F HET 2010 Yunnan Treatment naive V179D KF714374 BC F HET 2010 Yunnan Treatment naive V179D Demographic and clinical characteristics of 32 patients infected with CRF65_cpx ART antiretroviral therapy, M male, F female, HET heterosexual, IDU intravenous drug user, MSM men who have sex with men, NA not available As shown in the neighbor-joining phylogenetic tree (Fig.
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HIV Mutation Detail Information