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Mutation Information
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Mutation Site
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V179E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
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CRF07_BC;CRF01B;CRF01_AE |
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Viral Reference
|
AF503396;
JF906665;
HQ215583;
JQ901027;
JQ901094;
EF122515;
AY008714;
U51189;
JF906597;
JQ028206;
AF286229;
AY008717;
K03455;
U71182;
KF857447;
AY358072;
KC183783;
X52154 |
|
Relevant Drug
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nelfinavir (NFV);efavirenz (EFV);etravirine(ETR);rilpivirine (RPV);nevirapine (NPV);tipranavir (TPV) |
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Country
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China |
Literature Information
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PubMed PMID
|
28622345
|
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Disease
|
HIV infection/AIDS
|
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Published Year
|
2017 |
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Journal
|
PloS one |
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Title
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The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014. |
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Author
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Zeng P,Liu Y,He M,Wang J,Keating S,Mao W,Huang M,Ma H,He W,Bi X,Liao D,Busch M,Ness P,Liu J,Shan H,NHLBI Recipient Epidemiology and Donor Evaluation Study-III program. |
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Evidence
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31 specific DRMs were identified from 27 samples with DRMs distributing as: 1) 74.2% (23/31) DRMs were on nonnucleoside reverse transcriptase inhibitors (NNRTIs) as: V179E/D (n = 16), K238N (n = 2), E138A/G (n = 4) and G190E (n = 1). 2) Six protease inhibitors (PIs) DRMs were observed including, four PIs accessory DRMs: L23I (n = 1), K43T (n = 1) and Q58E (n = 2); and two PIs major DRMs: M46I. 3) Two nucleotide reverse transcriptase inhibitors (NRTIs) DRMs were: K219R and K70Q.
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HIV Mutation Detail Information