MCV Mutation Detail Information

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Mutation Information

Mutation Site	F391R
Mutation Type	Amino acid level
Gene/Protein/Region Type	Large T
Viral Reference	EU375804.1

Literature Information

PubMed PMID	21501625
Published Year	2011
Journal	Journal of molecular biology
Title	Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin.
Author	Harrison CJ,Meinke G,Kwun HJ,Rogalin H,Phelan PJ,Bullock PA,Chang Y,Moore PS,Bohm A
Evidence	One might expect that the mutation of Phe 391 to arginine would affect the affinity of OBDs bound to P2 and P4, but not P1, which would suggest that a two-site model could fit the calorimetric data better.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation