Mutation Information
Mutation Site
|
L142A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Small T |
Country
|
America |
Literature Information
PubMed PMID
|
21841310
|
Disease
|
Merkel cell carcinoma
|
Published Year
|
2011 |
Journal
|
The Journal of clinical investigation |
Title
|
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. |
Author
|
Shuda M,Kwun HJ,Feng H,Chang Y,Moore PS |
Evidence
|
2 proteins, with alanine substitutions at MCV sT arginine 7 (sT.R7A) or leucine 142 (sT.L142A), were expressed at levels comparable to the wild-type MCV sT protein (Figure (Figure4D),4D), but did not interact with PP2A Aα (Figure (Figure4E).4E).
|
|
|