MCV Mutation Detail Information

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Mutation Information
Mutation Site L142A
Mutation Type Amino acid level
Gene/Protein/Region Type Small T
Country America
Literature Information
PubMed PMID 21841310
Disease Merkel cell carcinoma
Published Year 2011
Journal The Journal of clinical investigation
Title Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator.
Author Shuda M,Kwun HJ,Feng H,Chang Y,Moore PS
Evidence 2 proteins, with alanine substitutions at MCV sT arginine 7 (sT.R7A) or leucine 142 (sT.L142A), were expressed at levels comparable to the wild-type MCV sT protein (Figure ​(Figure4D),4D), but did not interact with PP2A Aα (Figure ​(Figure4E).4E).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation