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Mutation Information
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Mutation Site
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E216K |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Large T |
Literature Information
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PubMed PMID
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21454559
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Published Year
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2011 |
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Journal
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The Journal of biological chemistry |
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Title
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Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus. |
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Author
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Liu X,Hein J,Richardson SC,Basse PH,Toptan T,Moore PS,Gjoerup OV,Chang Y |
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Evidence
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As seen in Fig. 6, substitution of lysine for glutamate at position 216 (LT.LXCXK),disrupts Rb interactions with LT (Fig. 6A) but has no effect on the hVam6p interaction with LT (Fig. 6B).
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MCV Mutation Detail Information