MCV Mutation Detail Information

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Mutation Information

Mutation Site	W76A
Mutation Type	Amino acid level
Gene/Protein/Region Type	VP1
Viral Reference	FJ392560.1

Literature Information

PubMed PMID	22910713
Published Year	2012
Journal	PLoS pathogens
Title	Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection.
Author	Neu U,Hengel H,Blaum BS,Schowalter RM,Macejak D,Gilbert M,Wakarchuk WW,Imamura A,Ando H,Kiso M,Arnberg N,Garcea RL,Peters T,Buck CB,Stehle T
Evidence	To probe the importance of sialic acid for MCPyV infection, we introduced mutations in the sialic acid binding site of MCPyV VP1 that either remove important interactions (W76A, Y81V, K295A) or create steric hindrance (S297N).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation