|
Mutation Information
|
Mutation Site
|
S220A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Large T |
|
Combined Mutation
|
Large T.S220A+Large T.S239A |
|
Viral Reference
|
JF813003.1
|
Literature Information
|
PubMed PMID
|
28461484
|
|
Published Year
|
2017 |
|
Journal
|
Proceedings of the National Academy of Sciences of the United States of America |
|
Title
|
Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence. |
|
Author
|
Kwun HJ,Chang Y,Moore PS |
|
Evidence
|
Mutations at two of these phosphoreceptor sites [serine (S)220 and S239] in the full viral genome increase LT levels and promote MCV virion production and transmission, which can be neutralized with anti-capsid antibody.
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MCV Mutation Detail Information