Literature Information
PubMed PMID
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28049147
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Published year
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2017 |
Journal
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mBio |
Title
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Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma. |
Author
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Starrett GJ,Marcelus C,Cantalupo PG,Katz JP,Cheng J,Akagi K,Thakuria M,Rabinowits G,Wang LC,Symer DE,Pipas JM,Harris RS,DeCaprio JA |
Evidence
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One chimeric junction was mapped at chr20:32132694 within CBFA2T2. Another chimeric junction was mapped between exon 1 of CBFA2T2 and the large T antigen splice acceptor at position 861 in MCPyV. One chimeric junction was mapped within an intron of FLJ46066 (approximately at chr3:182180601), indicating a chimeric transcript antisense to the FLJ46066 gene. The other three chimeric junctions mapped within the ECH1 (at host positions chr19:39307703 and chr19:39307378).Of the two tumors for which we also had whole-genome sequencing (WGS) data, sample-088 contained a single chimeric junction within two overlapping genes, RP3-348I23.2 and CDKAL1 (at chr6:20757000).
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