MCV Mutation Detail Information

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Mutation Information

Mutation Site	E146A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Small T
Viral Reference	KM359729.1

Literature Information

PubMed PMID	25631078
Published Year	2015
Journal	Journal of virology
Title	Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen.
Author	Kwun HJ,Shuda M,Camacho CJ,Gamper AM,Thant M,Chang Y,Moore PS
Evidence	Mutation of sT with alanine substitutions at six sites (including C109 [for which the corresponding residue has been commonly used in SV40 sT studies as a negative control], I122, L126, H130, E146, and Y150) markedly reduced sT protein stability and limited our ability to assess interactions and functional activities for these mutants

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation