MCV Mutation Detail Information

> K331R Search Result

Mutation Information

Mutation Site	K331R
Mutation Type	Amino acid level
Gene/Protein/Region Type	Large T
Viral Reference	EU375804.1

Literature Information

PubMed PMID	21501625
Published Year	2011
Journal	Journal of molecular biology
Title	Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin.
Author	Harrison CJ,Meinke G,Kwun HJ,Rogalin H,Phelan PJ,Bullock PA,Chang Y,Moore PS,Bohm A
Evidence	When Lys 331 was mutated to arginine, the affinity of the MCV OBD mutant became about one-third stronger than wild-type (Lys 331>Arg, KD ~550 nM), although it was still weaker than the SV40 OBD for Site II (Supplementary Figure 2B, Table I).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation