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Mutation Information
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Mutation Site
|
L142A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Small T |
Literature Information
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PubMed PMID
|
23954152
|
|
Published Year
|
2013 |
|
Journal
|
Cell host & microbe |
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Title
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Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. |
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Author
|
Kwun HJ,Shuda M,Feng H,Camacho CJ,Moore PS,Chang Y |
|
Evidence
|
Both sT and sT.L142A increased c-Myc expression and prolonged its turnover, an effect which is lost for sT.LSD91-95A.
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MCV Mutation Detail Information