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Mutation Information
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Mutation Site
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R7A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Small T |
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Country
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America |
Literature Information
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PubMed PMID
|
21841310
|
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Disease
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Merkel cell carcinoma
|
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Published Year
|
2011 |
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Journal
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The Journal of clinical investigation |
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Title
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Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. |
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Author
|
Shuda M,Kwun HJ,Feng H,Chang Y,Moore PS |
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Evidence
|
2 proteins, with alanine substitutions at MCV sT arginine 7 (sT.R7A) or leucine 142 (sT.L142A), were expressed at levels comparable to the wild-type MCV sT protein (Figure (Figure4D),4D), but did not interact with PP2A Aα (Figure (Figure4E).4E).
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MCV Mutation Detail Information