All Curated Mutation Sites in HBV

The VM annotation module provides researchers who are interested in VMs with annotations of reported pathogenic mutations in HBV related to human diseases easily. The curated mutation information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region or Disease
*Please select one option you are interested in, the page will be automatically redirected.
          
          


S1 Promoter
|
PreS1
|
S2 Promoter
|
PreS2
|
PreS
|
S PromoterII
|
S
|
RT
|
P
|
X Promoter
|
X
|
EnhI
|
EnhII
|
BCP
|
PreC
|
C Promoter
|
C
|

ID PMID Mutation Gene/Protein/Region Description Detail
1 19272629 P36L
PreS2
D
G
R
CI
C
View
2 15953865 23-55 DEL
PreS2
D
G
R
C
View
3 19889143 S28G
PreS2
G
R
S
C
View
4 19889143 H41Q
PreS2
G
R
S
C
View
5 19889143 D51G
PreS2
G
R
S
C
View
6 19889143 L20P
PreS2
G
R
S
C
View
7 19889143 T37A
PreS2
G
R
S
C
View
8 20119580 A11T
PreS2
G
R
CI
C
View
9 20119580 F22L
PreS2
G
R
CI
C
View
10 20119580 F46S
PreS2
G
R
CI
C
View
11 20119580 G19S
PreS2
G
R
CI
C
View
12 20119580 H9Q
PreS2
G
R
CI
C
View
13 20119580 I42T
PreS2
G
R
CI
C
View
14 20119580 I45T
PreS2
G
R
CI
C
View
15 20119580 L20Q
PreS2
G
R
CI
C
View
16 20119580 N4K
PreS2
G
R
CI
C
View
17 20119580 P54L
PreS2
G
R
CI
C
View
18 20119580 P54Q
PreS2
G
R
CI
C
View
19 20119580 R16G
PreS2
G
R
CI
C
View
20 20119580 R16P
PreS2
G
R
CI
C
View
21 20119580 R18S
PreS2
G
R
CI
C
View
22 20119580 T49I
PreS2
G
R
CI
C
View
23 20119580 T7A
PreS2
G
R
CI
C
View
24 20119580 V17A
PreS2
G
R
CI
C
View
25 20119580 V17P
PreS2
G
R
CI
C
View
26 20119580 V32A
PreS2
G
R
CI
C
View
27 23029487 A53V
PreS2
R
S
CI
C
View
28 23029487 Q10R
PreS2
R
S
CI
C
View
29 23029487 R48K
PreS2
R
S
CI
C
View
30 23029487 R48T
PreS2
R
S
CI
C
View
31 23865777 F22L
PreS2
G
R
S
C
View
32 23978387 F22L
PreS2
G
R
S
C
View
33 27182775 M1I
PreS2
G
R
S
C
View
34 30584239 M1I
PreS2
R
S
I
C
View
35 30584239 M1V
PreS2
R
S
I
C
View
36 32504396 T64C
PreS2
G
R
S
C
View
37 32504396 F22L
PreS2
G
R
S
C
View
38 15953865 12_22DEL
PreS2
D
G
C
View
39 19431214 M1I
PreS2
G
R
C
View
40 19431214 Q2K
PreS2
G
R
C
View
41 20573234 T168A
PreS2
G
R
C
View
42 20962085 F141L
PreS2
G
R
C
View
43 20962085 M120V
PreS2
G
R
C
View
44 24006435 A1C
PreS2
G
S
C
View
45 24006435 A31T
PreS2
G
S
C
View
46 24006435 T49A
PreS2
G
S
C
View
47 24006435 A52C
PreS2
G
S
C
View
48 24006435 G105C
PreS2
G
S
C
View
49 24006435 C109A
PreS2
G
S
C
View
50 24006435 A135C
PreS2
G
S
C
View
51 24006435 C7A
PreS2
G
S
C
View
52 24006435 G147C
PreS2
G
S
C
View
53 24632784 R16K
PreS2
G
S
C
View
54 24632784 R18K
PreS2
G
S
C
View
55 27486882 19-22 DEL
PreS2
G
R
C
View
56 27486882 G99E
PreS2
G
R
C
View
57 27486882 I147T
PreS2
G
R
C
View
58 27486882 F75S
PreS2
G
R
C
View
59 27486882 Q184H
PreS2
G
R
C
View
60 27486882 H114T
PreS2
G
R
C
View
61 27486882 I165L
PreS2
G
R
C
View
62 28859616 T53C
PreS2
G
S
C
View
63 28859616 A162G
PreS2
G
S
C
View
64 28859616 T531C
PreS2
G
S
C
View
65 28859616 T531G
PreS2
G
S
C
View
66 28859616 M1V
PreS2
G
S
C
View
67 28859616 M1T
PreS2
G
S
C
View
68 28859616 M1I
PreS2
G
S
C
View
69 28859616 F22I
PreS2
G
S
C
View
70 28859616 N3S
PreS2
G
S
C
View
71 28859616 L126T
PreS2
G
S
C
View
72 28859616 L126S
PreS2
G
S
C
View
73 28859616 F22L
PreS2
G
S
C
View
74 29642827 A53V
PreS2
G
S
C
View
75 29642827 D14N
PreS2
G
S
C
View
76 29642827 D51G
PreS2
G
S
C
View
77 29642827 D51V
PreS2
G
S
C
View
78 29642827 F22L
PreS2
G
S
C
View
79 29642827 F22S
PreS2
G
S
C
View
80 29642827 F46Y
PreS2
G
S
C
View
81 29642827 F8S
PreS2
G
S
C
View
82 29642827 G19D
PreS2
G
S
C
View
83 29642827 G19S
PreS2
G
S
C
View
84 29642827 G30E
PreS2
G
S
C
View
85 29642827 H9Q
PreS2
G
S
C
View
86 29642827 I42L
PreS2
G
S
C
View
87 29642827 I42T
PreS2
G
S
C
View
88 29642827 I45T
PreS2
G
S
C
View
89 29642827 I49T
PreS2
G
S
C
View
90 29642827 L54G
PreS2
G
S
C
View
91 29642827 L54R
PreS2
G
S
C
View
92 29642827 M1V
PreS2
G
S
C
View
93 29642827 N33T
PreS2
G
S
C
View
94 29642827 N55K
PreS2
G
S
C
View
95 29642827 P41H
PreS2
G
S
C
View
96 29642827 P41L
PreS2
G
S
C
View
97 29642827 P52L
PreS2
G
S
C
View
98 29642827 Q13L
PreS2
G
S
C
View
99 29642827 Q2R
PreS2
G
S
C
View
100 29642827 R16K
PreS2
G
S
C
View
101 29642827 R18K
PreS2
G
S
C
View
102 29642827 R48K
PreS2
G
S
C
View
103 29642827 S28T
PreS2
G
S
C
View
104 29642827 S47L
PreS2
G
S
C
View
105 29642827 S5H
PreS2
G
S
C
View
106 29642827 V39A
PreS2
G
S
C
View
107 30835025 M1I
PreS2
G
R
C
View
108 30835025 M1T
PreS2
G
R
C
View
109 30835025 M1V
PreS2
G
R
C
View
110 31501793 M109T
PreS2
G
R
C
View
111 31501793 S130F
PreS2
G
R
C
View
112 31501793 S130L
PreS2
G
R
C
View
113 10534721 S44L
PreS2
G
C
View
114 10534721 R48K
PreS2
G
C
View
115 10534721 P52L
PreS2
G
C
View
116 16847965 N152S
PreS2
G
R
View
117 16847965 N174T
PreS2
G
R
View
118 16847965 P155Q
PreS2
G
R
View
119 17258721 Q2K
PreS2
G
R
View
120 17258721 H9Q
PreS2
G
R
View
121 17258721 S29P
PreS2
G
R
View
122 17258721 S85P
PreS2
G
R
View
123 17258721 R18K
PreS2
G
R
View
124 17503077 A53V
PreS2
G
C
View
125 17825452 N33S
PreS2
G
R
View
126 17825452 F46L
PreS2
G
R
View
127 17825452 L41S
PreS2
G
R
View
128 17825452 H41S
PreS2
G
R
View
129 17825452 P41S
PreS2
G
R
View
130 17825452 A41S
PreS2
G
R
View
131 17825452 I45T
PreS2
G
R
View
132 17825452 A39S
PreS2
G
R
View
133 17825452 V39S
PreS2
G
R
View
134 17825452 L41I
PreS2
G
R
View
135 17825452 H41I
PreS2
G
R
View
136 17825452 P41I
PreS2
G
R
View
137 17825452 A41I
PreS2
G
R
View
138 17825452 F46G
PreS2
G
R
View
139 17825452 L46G
PreS2
G
R
View
140 17825452 S46G
PreS2
G
R
View
141 18939932 M1V
PreS2
R
C
View
142 18939932 M1I
PreS2
R
C
View
143 18939932 M1A
PreS2
R
C
View
144 18939932 Q2K
PreS2
R
C
View
145 18939932 Q2R
PreS2
R
C
View
146 20699378 T53C
PreS2
R
C
View
147 22012717 F141L
PreS2
G
C
View
148 22720022 F22L
PreS2
S
C
View
149 23386590 C2875A
PreS2
S
C
View
150 23386590 A31C
PreS2
S
C
View
151 23386590 A31T
PreS2
S
C
View
152 23386590 T49A
PreS2
S
C
View
153 23386590 A52C
PreS2
S
C
View
154 23386590 A52T
PreS2
S
C
View
155 23386590 G105C
PreS2
S
C
View
156 23386590 G105T
PreS2
S
C
View
157 23386590 C109A
PreS2
S
C
View
158 23386590 C109T
PreS2
S
C
View
159 23386590 A135C
PreS2
S
C
View
160 23386590 G147C
PreS2
S
C
View
161 23386590 T53C
PreS2
S
C
View
162 23386590 F141L
PreS2
S
C
View
163 23386590 A1C
PreS2
S
C
View
164 23386590 A1T
PreS2
S
C
View
165 23386590 C31C
PreS2
S
C
View
166 23386590 C31T
PreS2
S
C
View
167 23386590 C7A
PreS2
S
C
View
168 23386590 C76A
PreS2
S
C
View
169 23865777 I42T
PreS2
S
C
View
170 24409056 F22L
PreS2
G
C
View
171 24409056 M1I
PreS2
G
C
View
172 24409056 M1T
PreS2
G
C
View
173 25351410 T3205A
PreS2
R
C
View
174 25351410 S162T
PreS2
R
C
View
175 25351410 C3165A
PreS2
R
C
View
176 27727182 T31C
PreS2
R
C
View
177 27727182 T53C
PreS2
R
C
View
178 27727182 M1V
PreS2
R
C
View
179 27727182 M1T
PreS2
R
C
View
180 27727182 M1I
PreS2
R
C
View
181 27727182 F22L
PreS2
R
C
View
182 28332361 A11T
PreS2
R
C
View
183 28332361 G19D
PreS2
R
C
View
184 28332361 I42T
PreS2
R
C
View
185 28332361 N33H
PreS2
R
C
View
186 28332361 F22L
PreS2
R
C
View
187 28332361 D14N
PreS2
R
C
View
188 28332361 R16K
PreS2
R
C
View
189 28332361 G30E
PreS2
R
C
View
190 28332361 P54Q
PreS2
R
C
View
191 28332361 P54T
PreS2
R
C
View
192 28376292 4INSG
PreS2
G
C
View
193 28376292 F22S
PreS2
G
C
View
194 33803998 F141L
PreS2
G
S
View
195 12974898 G149R
PreS2
C
View
196 17258721 C4A
PreS2
G
View
197 17258721 C27A
PreS2
G
View
198 17258721 T85C
PreS2
G
View
199 17258721 G53A
PreS2
G
View
200 17503077 D51G
PreS2
C
View
201 17503077 F46S
PreS2
C
View
202 17503077 I49T
PreS2
C
View
203 17503077 P54L
PreS2
C
View
204 17503077 P52L
PreS2
C
View
205 17503077 A39V
PreS2
C
View
206 17503077 T31A
PreS2
C
View
207 20160279 T31C
PreS2
C
View
208 21108338 C105T
PreS2
C
View
209 21108338 T105C
PreS2
C
View
210 21108338 C1A
PreS2
C
View
211 21108338 C1G
PreS2
C
View
212 21108338 C135A
PreS2
C
View
213 21108338 C135T
PreS2
C
View
214 21108338 A7C
PreS2
C
View
215 21108338 A10C
PreS2
C
View
216 21108338 A10T
PreS2
C
View
217 21108338 C31A
PreS2
C
View
218 21108338 C31T
PreS2
C
View
219 21108338 A49G
PreS2
C
View
220 21108338 A49T
PreS2
C
View
221 21108338 C52A
PreS2
C
View
222 21108338 C52T
PreS2
C
View
223 21108338 T53C
PreS2
C
View
224 21108338 A109C
PreS2
C
View
225 21108338 A109T
PreS2
C
View
226 23951004 V39A
PreS2
C
View
227 23951004 L54P
PreS2
C
View
228 24849936 T31C
PreS2
C
View
229 24849936 T53C
PreS2
C
View
230 25501679 C105T
PreS2
C
View
231 27486882 P41H
PreS2
G
View
232 27486882 P66L
PreS2
G
View
233 30943997 V32L
PreS2
G
View
234 30943997 N33S
PreS2
G
View
235 30943997 A35V
PreS2
G
View
236 30943997 N37T
PreS2
G
View
237 30943997 A47S
PreS2
G
View
238 30943997 T49I
PreS2
G
View
239 30943997 V53A
PreS2
G
View
240 30943997 T54P
PreS2
G
View
241 32722114 1-54 DEL
PreS2
C
View
242 24282423 N123S
PreS2
View
243 24282423 N15S
PreS2
View
244 24282423 N177S
PreS2
View
245 24282423 N320K
PreS2
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
Drugs mentioned in the relevant literature.
G
Genotypes/subtypes mentioned in the relevant literature.
R
Reference genomes mentioned in the relevant literature.
S
Viral sequences mentioned in the relevant literature.
C
Geographical distribution of the source mentioned in the relevant literature.
CI
Clinical information is available in the relevant literature.
I
This mutation is related to the immune escape.

Copyright © 2021.Tongji University, Life Science and Technology Department, Xiaoyan Zhang Lab.