|
Mutation Information
|
Mutation Site
|
F22L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PreS2 |
|
Genotype/Subtype
|
A |
|
Viral Reference
|
AY233274.1
|
|
Country
|
Black South African |
Literature Information
|
PubMed PMID
|
32504396
|
|
Disease
|
Hepatocellular carcinoma
|
|
Published Year
|
2020 |
|
Journal
|
Archives of virology |
|
Title
|
Molecular characterization of hepatitis B virus isolated from Black South African cancer patients, with and without hepatocellular carcinoma. |
|
Author
|
Mak D,Kramvis A |
|
Evidence
|
The following mutations were significantly more frequent in HCC cases than in controls (p < 0.05): in the BCP/PC 1753C/G (22.5% vs. 0%), 1764A (69.4% vs. 38.1%), and T64C (51.5% vs. 20%) in the preS2, which results in a F22L substitution.
|
|
|
HBV Mutation Detail Information