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Mutation Information
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Mutation Site
|
H114T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PreS2 |
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Genotype/Subtype
|
D |
|
Viral Reference
|
AY090460;
AY090457;
AY090454;
AF405706;
AB064310;
AF160501;
AF223965;
AB036910;
X69798;
AB032431;
X75657;
X85254;
M32138;
X65259;
AB014381;
M12906;
X04615;
AB033554;
AF100309;
D00329;
AF090842;
X51970;
X02763 |
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
27486882
|
|
Disease
|
Occult HBV infection;
Hepatocellular carcinoma;
Liver cirrhosis
|
|
Published Year
|
2016 |
|
Journal
|
Oncotarget |
|
Title
|
Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study. |
|
Author
|
Coppola N,Onorato L,Iodice V,Starace M,Minichini C,Farella N,Liorre G,Filippini P,Sagnelli E,de Stefano G |
|
Evidence
|
The following AA substitutions and deletions were observed: a) G44E, I92T, Q129H, N59T, and I110L AA substitutions in the S region; b) AA deletions in position 128-131 and G91A, I255T, S98T, N310D, T114I, and T119P AA substitutions in the pre-S1 region; c) AA deletions in position 19-22 and G99E, I147T, F75S, Q184H, H114T and I165L AA substitutions in the pre-S2 region (Table (Table33).
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HBV Mutation Detail Information