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Mutation Information
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Mutation Site
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C105T |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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PreS2 |
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Country
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China |
Literature Information
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PubMed PMID
|
21108338
|
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Disease
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Hepatocellular carcinoma
|
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Published Year
|
2011 |
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Journal
|
Journal of medical virology |
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Title
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A matched case-control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma. |
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Author
|
Liu S,Xie J,Yin J,Zhang H,Zhang Q,Pu R,Li C,Ni W,Wang H,Cao G |
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Evidence
|
Multivariate analyses established that genotype C (adjusted odds ratio [AOR] = 3.3; 95% confidence interval [CI] = 1.1-9.8), viral load (>=10(4) copies/ml) (AOR = 2.4; 95% CI = 1.0-5.8), A2962G (AOR = 18.7; 95% CI = 7.5-46.7), preS2 start codon mutation (AOR = 12.5; 95% CI = 3.4-45.5), C105T (AOR = 0.1; 95% CI = 0.0-0.2), T1753V (AOR = 3.1; 95% CI = 1.1-9.2), and A1762T/G1764A (AOR = 2.9; 95% CI = 1.1-7.3) were associated independently with HCC, adjusted for factors including mutations in both regions.
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HBV Mutation Detail Information