Mutation Information
Mutation Site
|
G105C |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
PreS2 |
Genotype/Subtype
|
B;C |
Country
|
China |
Literature Information
PubMed PMID
|
24006435
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2013 |
Journal
|
Journal of virology |
Title
|
HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations. |
Author
|
Zhang Q,Yin J,Zhang Y,Deng Y,Ji X,Du Y,Pu R,Han Y,Zhao J,Han X,Zhang H,Cao G |
Evidence
|
Importantly, the frequencies of significant HBV mutations (A1C, A31T, T49A, A52C, G105C, C109A, A135C, and G147C in genotype B and A1C, C7A, C10A, A31T, T49A, A52C, G105C, C109A, A135C, and G147C in genotype C) in the pre-S2 region were extremely low (0.0% in genotype B and 0.0% to 4.2% in genotype C) in ASCs but equally high in the CHB patients, HC patients, and HCC patients (92.3% to 100.0% in genotype B and 89.7% to 100.0% in genotype C).
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